Dementia rates in the US, UK, Netherlands, Sweden, France, and several other high-income countries have been falling for decades, despite population aging. The standard explanation — improved cardiovascular care, more education, and less smoking in later-born cohorts — is real but incomplete. Research Highlights Dementia incidence has been falling about 13% per decade in Western …
A preprint in 84 older adults with epilepsy found that abnormal Alzheimer's-related blood biomarkers were common, but the biomarker categories did not line up neatly with cognitive impairment. Research Highlights Only 32.1% had normal biomarkers: 27 of 84 older adults with epilepsy were A−T−N− using blood-based amyloid, tau, and neurodegeneration markers.1 AD-continuum profiles were common: …
A 2026 medRxiv preprint found that older adults with mild-cognitive-impairment-level MoCA-J scores showed distinct resting facial action-unit patterns: AU10 upper lip raiser, AU23 lip tightener, and AU28 lip suck differed after correction in 45 analyzable participants.1 The result supports facial-expression screening research, but it does not show that a face video can diagnose MCI or …
A 430-caregiver study in Kathmandu found caregiving burden in 65.3% of family caregivers of older adults with disability, with adjusted predictors clustering around low economic status, 8 or more daily care hours, and severe impairment in activities of daily living.1 Research Highlights Burden was the majority experience: 65.3% of 430 family caregivers reported caregiving burden …
A 2026 Medicare target-trial emulation found continued levetiracetam after acute ischemic stroke was associated with 53 vs. 62 deaths per 1,000 over 90 days, a risk difference of −9 deaths per 1,000 favoring continuation. Research Highlights Survival signal: continued levetiracetam after an initial month of post-stroke use was linked to 53 deaths per 1,000 vs. …
A 2026 individual participant data meta-analysis of 1,721 dementia trial participants linked risperidone to cerebrovascular adverse events, HR 4.11 (95% CI 1.77 to 9.51), and major cardiovascular adverse events, HR 2.00 (95% CI 1.23 to 3.26).1 The timing signal is the practical warning: median first cerebrovascular event appeared at 4.3 weeks, and median first major …
A 2025 longitudinal analysis of 1,528 older Chinese Americans by Chen et al. in the Journal of Prevention of Alzheimer’s Disease says something more specific than “stress causes Alzheimer’s”: it isn’t the count of stressors that tracks memory decline — it’s a latent trait the authors call stress internalization, a bundle of high perceived stress, …