MentalHealthDaily

Catatonia Linked to Lower Left Paracingulate Sulcus Rate (28% vs 53%)

by GLOOM

Photoreal illustration of a brain with the anterior cingulate cortex highlighted, representing transdiagnostic structural markers of catatonia.

A 2026 hospital MRI study found that the left paracingulate sulcus was present in 31 of 109 catatonia patients (28%) vs. 171 of 323 psychiatric controls without catatonia (53%), a left-hemisphere group effect that survived adjustment for age, sex, scanner, brain volume, benzodiazepines, and antipsychotics.1 Research Highlights Left PCS signal: left paracingulate sulcus (PCS) presence …

Melatonin Phases & Circadian Rhythms vs. Depression & Anhedonia Severity (2024 Study)

by GLOOM

In the intricate world of mental health, the rhythms of our body’s natural processes play a pivotal role, particularly the circadian rhythm of melatonin, a hormone primarily produced by the pineal gland. Recent research suggests that variations in melatonin’s circadian rhythm might not only distinguish between depression and bipolar disorder but also correlate with the …