Celecoxib for Depression: 7 Trials, Add-On Benefit Unclear
A 7-trial review favored adding celecoxib to antidepressants for depression, but its benefit was not confirmed after 3 high-risk trials were excluded.
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Published research on depression treatment.
PReDicT Antidepressant Algorithm Cost-Effectiveness Was Uncertain
A 913-person economic evaluation of the PReDicT antidepressant algorithm found nearly identical EQ-5D quality-of-life gains vs. treatment as usual (+0.139 vs. +0.140) and nearly identical so…
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Electroacupuncture for Depression Has Mechanisms, Not Firm Trial Proof
A 2026 review of electroacupuncture for depression found a familiar split: mechanistic evidence is rich, but clinical proof remains uneven because representative trials ranged from 65 to 270…
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Antidepressant Use in Pakistan (2026): SSRI Prescribing Patterns and Patient-Reported Side Effects
Most antidepressant pharmacovigilance data come from high-income countries, leaving prescribing patterns and adverse-effect profiles in low- and middle-income countries underdocumented. A 20…
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Xylopic Acid for Depression: May Increase Efficacy of Select Antidepressants via Synergistic Effect (2024 Study)
In a new study, researchers discovered the synergistic antidepressant-like effects of xylopic acid (XA), a natural compound extracted from the dried fruits of Xylopia aethiopica, when combin…
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Abnormal Brain EEG Activity Doesn’t Predict Antidepressant Efficacy in Depression (2023 Study)
Depression is a multifaceted mental health condition that presents significant challenges in both diagnosis and treatment. Recent studies have explored the potential of electroencephalograph…
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tDCS of the DLPFC Treats Anhedonia in Depression & Improves Social Functioning (2024 Study)
In the quest to find more effective treatments for depression, particularly the challenging symptom of anhedonia, Transcranial Direct Current Stimulation (tDCS) emerges as a promising option…
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