A 2026 target-trial emulation involving 102,361 U.S. veterans with type 2 diabetes found no increased suicidality risk after starting semaglutide vs. sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors): suicidal ideation HR 0.99 and suicide attempt/death HR 1.05 after overlap weighting.1 That does not prove semaglutide prevents suicide, but it weakens the broad claim that semaglutide initiation itself …
A 91-player adolescent football preprint mapped head-impact-related cortical slowing onto brain receptor and gene-expression maps: concussion-related slowing aligned with norepinephrine transporter density, r = 0.43, and alpha-4 beta-2 nicotinic receptor density, r = 0.50, while aligning inversely with dopamine D2, BDNF, and APOE maps.1 The result is a mechanistic clue about where head-impact physiology may …
An Ethiopian umbrella review estimated perinatal depressive symptoms at 22.49% across 8 systematic reviews and meta-analyses. Antenatal and postnatal rates were similar, so the burden spans the whole perinatal window rather than clustering only after delivery.1 Research Highlights Overall pooled prevalence was 22.49%: Necho et al. combined 8 Ethiopian systematic reviews and meta-analyses covering 28 …
A Global Burden of Disease analysis estimated that U.S. age-standardized substance-use disorder disability-adjusted life-year rates rose 213.5% from 1990 to 2019, with opioid use disorders producing the steepest increase and the largest state-level burden.1 Research Highlights U.S. cases rose sharply: prevalent substance-use disorder cases increased from 12.6 million in 1990 to 19.5 million in 2019.1 …
A 2026 medRxiv preprint used 68 NeuroMark SPECT components to analyze 2,746 psychiatric patient scans and 76 controls, linking depression-related worry/rumination and social disinterest to brain-network patterns.1 This preprint is useful as a large biomarker-generating map, but the clinical-diagnostic claim needs much more caution than the sample size alone suggests. Research Highlights Large clinical SPECT …
A 2026 PLOS One study fine-tuned Qwen-2.5 and GLM-4 for psychology questionnaire generation and reported the largest gain in readability and comprehension difficulty: 3.41 to 4.66 on a 0–5 scale, a 36.7% relative improvement.1 The result supports item drafting inside a psychometric workflow, while clinical or research scale use still requires ordinary validation. Research Highlights …
A 2026 nationally-representative study by Johnson, Parker, and Wade in the Canadian Journal of Psychiatry tested ACE-style screening in 7,608 Canadian adults and replicated what US, UK, and New Zealand cohorts already found: predictive accuracy is poor, with AUCs of 0.62 to 0.67 across anxiety, mood, substance use, and suicidality — all below the conventional …