A 2026 systematic review argues that catatonia should be read as a limbic-cortical circuit syndrome, with motor shutdown tied to brain systems for threat, salience, motivation, and emotional regulation. Research Highlights 20 studies met criteria: the 2026 review screened 1,792 records, assessed 54 full texts, and included 20 articles: 13 observational studies and 7 case …
Violence exposure was nearly universal by age 8 in a South African birth cohort: 91.1% of children had experienced at least 1 violence type, and 53.6% had experienced more than 1. Recent violence exposure at age 8 was consistently tied to mental-health problems, while earlier exposure at age 4.5 showed weaker longitudinal prediction than same-age …
A 2026 case-control imaging study found that 23 women with premenstrual dysphoric disorder had higher left DTI-ALPS glymphatic index than 27 healthy controls (p = 0.024), plus wider hypothalamus connectivity across emotion and subcortical networks.1 The result adds a brain-fluid-clearance and stress-network layer to PMDD biology, but the evidence is still small-sample imaging rather than …
A 2026 cross-sectional schizophrenia study found no meaningful association between antipsychotic dose and Montreal Cognitive Assessment (MoCA) performance in young, clinically stable outpatients. Cognitive scores related more strongly to symptom burden, illness duration, education, and age at diagnosis than to daily or 1-year cumulative antipsychotic exposure.1 Research Highlights Daily dose was not linked to MoCA: …
A 2026 national survey of Dutch emergency physicians found wide variation in first-line medication choices for extreme agitation: without intravenous access, 34.7% preferred midazolam, 23.1% preferred droperidol, 14.3% preferred droperidol plus midazolam, and 10.4% preferred esketamine.1 The result is a practice map, not an outcome trial, but it shows how emergency clinicians are balancing rapid …
The structural determinants of mental health get less air time than individual treatments, but a 2025 CDC analysis of 3,121 US counties from Bolduc et al. shows just how much county-level economics moves population mental health: a model built from 11 economic variables explains roughly 70% of the variation in adult poor-mental-health prevalence across the …
A 2026 PREDIMED-Plus cohort analysis linked higher olive-oil intake with 2-year cognitive preservation in 656 older adults, with each 10 g/day increment associated with higher global cognition change compared with lower intake (beta 0.044 z-score; 95% CI 0.013 to 0.075; p = 0.006).1 The more specific signal favored virgin olive oil and gut-microbiome diversity, while …