A 2026 individual participant data meta-analysis of 1,721 dementia trial participants linked risperidone to cerebrovascular adverse events, HR 4.11 (95% CI 1.77 to 9.51), and major cardiovascular adverse events, HR 2.00 (95% CI 1.23 to 3.26).1 The timing signal is the practical warning: median first cerebrovascular event appeared at 4.3 weeks, and median first major …
A 2026 immunopsychiatry cohort study found that soluble CD27 (sCD27), a marker of T-cell activation, was positive in cerebrospinal fluid in 23% of severe psychiatric patients selected for suspected immune involvement and in 88% of multiple sclerosis patients used as a positive-control group. In the psychiatric cohort, combined cerebrospinal fluid or blood sCD27 positivity was …
A 2026 Saudi tertiary-hospital study estimated that adults treated for fibromyalgia — chronic widespread pain with fatigue, sleep disruption, cognitive symptoms, and overlapping mood or medical problems — generated SAR 9,601.2 (USD 2,560.3) in annual direct medical costs per patient, with specialist visits and diagnostic procedures accounting for 96.3% of recorded spending.1 Research Highlights Annual …
A 2026 psychometric study of 354 Swedish participants found that 1-week versions of the PHQ-15 and SSD-12 mostly preserved internal consistency and construct validity, but reliability was acceptable mainly in clinical participants or when researchers averaged 2 timepoints. Research Highlights Clinical tracking looked more defensible than healthy screening: Hybelius et al. studied 194 people with …
A 2026 ABCD Study preprint involving 11,868 youth found stable time-ordered predictors of teen substance-use initiation, but the adjusted effects were small: most estimates ranged from −0.01 to 0.02 initiation-probability points per 1-SD predictor increase. Research Highlights Large ABCD panel: Wei et al. analyzed 11,868 youth with repeated observations and interval-level initiation outcomes for alcohol, …
A 2026 Han Chinese case-control preprint linked the MTHFR C677T variant to schizophrenia with type 2 diabetes: the 677T allele appeared in 81.67% of alleles in the comorbid group vs. 60.00% in controls (p = 0.009), while MTHFR promoter methylation was nearly saturated in both groups (95.00% vs. 90.00%; p = 1.000). Research Highlights Genetic …
A 2026 cross-sectional study in Moshi, Tanzania found that only 26 of 246 injury patients who drank alcohol, or 10.6%, had ever told a healthcare provider about their alcohol use.1 The calibration result was contrary to the prediction: measured alcohol stigma did not track disclosure, while alcohol-related consequences did. Research Highlights Disclosure was rare: among …