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Maternal Health and Autism Risk: Most Links Are Genetic, Not Prenatal

Stylized illustration of a multi-generation family tree branching into cousin pairs, representing the 3-generation registry design used to separate inherited from in-utero genetic effects on autism risk.

For two decades, headlines have linked autism to maternal obesity, depression, anxiety, gestational diabetes, infection, autoimmune disease, and antidepressant use. The studies behind those headlines are well-replicated registry associations. A new design from the Aarhus University iPSYCH group offers the most careful answer yet to what they mean for an individual pregnancy. Most “maternal X …

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Ketamine Addiction After One Therapeutic Dose: How Rare Is It?

Stylized illustration evoking the tension between ketamine's clinical promise for depression and its abuse liability, framed in muted rose and amber tones for the addiction topic.

Ketamine and its S-enantiomer esketamine (sold as Spravato) are now established treatments for treatment-resistant depression and acute suicidality. The standard safety pitch from sponsors and clinics: at single sub-anesthetic doses, in supervised settings, addiction risk is minimal. A new case report in BJPsych Open documents a patient for whom that pitch failed catastrophically — and …

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Lupus Psychosis: 4.5% Prevalence and Antibody Predictors

Stylized illustration of autoantibodies and immune complexes crossing a disrupted blood-brain barrier, evoking the immune-mediated mechanism by which lupus produces psychosis.

Psychosis is one of 19 neuropsychiatric syndromes the American College of Rheumatology recognizes as attributable to systemic lupus erythematosus (SLE), an autoimmune disease that disproportionately affects young women.2 A 2026 systematic review and meta-analysis from Parperis and colleagues in Lupus pooled 65 studies and 31,495 patients.1 The synthesis matters less for the headline 4.5% prevalence …

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Mass Social Media Illness with Tourette-Like Behavior Tics vs. Tourette Syndrome: What Are the Differences? (2023 Study)

In recent years, the medical community has observed a perplexing surge in cases of functional Tourette-like behaviors (FTB), attributed significantly to the influence of social media. Dubbed Mass Social Media-Induced Illness (MSMI), this phenomenon marks a departure from traditional understandings of mass sociogenic illness, leveraging virtual platforms to spread across global populations. Highlights: Surge Since …

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Personalized TMS for Psychiatric Disorders: Targeting Functional Connectivity (FC) in the Brain (2024 Review)

Transcranial Magnetic Stimulation (TMS) has emerged as a beacon of hope in the realm of psychiatry, offering a non-invasive alternative for treating psychiatric disorders. The variability in treatment outcomes highlights the necessity for advancements in personalized approaches. A recent paper analyzed the potential of personalized TMS protocols (customized based on individual brain connectivity) may help …

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Genetics of Female Reproductive Behaviors & Psychiatric Disorders: Age of First Sexual Intercourse Significant (2023 Study)

The complex interplay between reproductive behaviors and psychiatric disorders is an area of interest within the scientific community, revealing how our genetic makeup may influence both our reproductive milestones and mental health. A recent study sheds light on this relationship, focusing on the causal pathways linking reproductive behaviors, such as the age at first sexual …

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