MentalHealthDaily

Esketamine Failed Cost-Effectiveness vs. Cheaper TRD Options at $50K/QALY

by GLOOM

Photoreal illustration of a depression-treatment decision with cost and outcome imagery, conveying healthcare-economic decision-making.

Intranasal esketamine — FDA-approved for treatment-resistant depression in 2019 — failed cost-effectiveness benchmarks against four cheaper third-line options in a 2026 Hong Kong modeling study, with incremental cost-effectiveness ratios (ICERs) of US$134,127 to US$312,750 per quality-adjusted life-year (QALY) at a US$50,000/QALY willingness-to-pay (WTP) threshold.1 Combination antidepressant therapy was the most cost-effective strategy modeled. Research Highlights …

ADHD in Chronic Pain Clinics: 1 in 6 Screen Positive

by GLOOM

Photoreal illustration of an adult holding their head in pain with cognitive-affective overlay imagery, representing ADHD and chronic pain comorbidity.

A 2026 study of 958 adults entering Japanese multidisciplinary pain centers found that 17.1% screened positive for ADHD, rising to 27.4% among patients whose average pain was NRS 9-10; ASD screening was 4.4% overall and did not show the same pain-intensity signal.1 Research Highlights ADHD screening was elevated in tertiary pain care: 164 of 958 …

Copy Number Variants Did Not Moderate ADHD or Autism Outcomes in ALSPAC

by GLOOM

Photoreal illustration of DNA strands and developmental timeline overlaid on a schematic young adult, conveying genetic moderation of childhood neurodevelopmental outcomes.

A 2026 ALSPAC analysis tested a narrow claim behind routine genetic screening for childhood attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD): whether rare copy number variants (CNVs; deleted or duplicated DNA segments) make young-adult outcomes worse than ADHD/ASD status alone would predict. In 8,414 people with usable CNV data, ADHD and ASD predicted worse …

Cognitive Reserve in First-Episode Psychosis: Education PRS Adds 4.2%

by GLOOM

Photoreal illustration of brain with strengthening neural networks suggesting reserve and protection against cognitive decline.

A 2026 analysis of 174 people with non-affective first-episode psychosis found that cognitive reserve was tied to 3 signals available near illness onset: age at onset, family history of psychosis, and polygenic liability for educational attainment. Adding the education polygenic score raised the model’s adjusted R² from 13.5% to 17.7%, a real but modest gain …

1 mg Guanfacine for Self-Harm Thoughts in ADHD-PTSD-BPD Case

by GLOOM

MHD featured image for 1 mg guanfacine and self-harm thoughts in complex ADHD, PTSD, BPD, and ASD comorbidity.

A 2026 case report linked 1 mg nightly guanfacine modified-release to first-ever cessation of intrusive deliberate self-harm thoughts in a 16-year-old with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) traits, borderline personality disorder (BPD) traits, and post-traumatic stress disorder (PTSD). The same case became more interesting after the patient stopped taking guanfacine and the self-harm …

IV Clomipramine Shows No Clear Edge in Depression or OCD

by GLOOM

Photoreal illustration of an IV infusion bag and capsule with brain imagery, conveying parenteral vs oral antidepressant pharmacokinetics.

Parenteral clomipramine has a strong clinical myth around it: bypass the gut, raise parent-drug exposure quickly, and maybe accelerate rescue in severe depression or OCD. A 2026 systematic review found the route advantage was not clearly proven: in depression, 5 RCTs without high risk of bias did not show clear IV or IM superiority over …

Only 5 of 50 NHS Trusts Could Count Psychiatric Inpatient Parents

by GLOOM

Photoreal illustration of a family room in psychiatric inpatient setting, conveying parent-child connection during parental hospitalization.

A 2026 Freedom of Information survey of all 50 English NHS trusts providing inpatient psychiatric care found a basic visibility failure: only 5 trusts could say how many psychiatric inpatients were parents, only 11 could describe routine parental-status data collection, and only 1 held child-visit data.1 Research Highlights Parent counts were mostly unavailable: 5 of …