A self-localized ultrafast pencil beam is not a brain treatment, but it could become useful imaging infrastructure for neuroscience and drug-delivery research. In an arXiv preprint, Cao et al. generated a stable ultrafast beam inside a standard multimode fiber and used it for volumetric multiphoton imaging of intact mouse enteric nervous tissue and a live …
A 2026 mouse study found that long-term CoQ10 exposure reduced working-memory errors in Purkinje-cell-specific Drp1-deficient mice, tying the behavioral rescue to Coa6 binding and support for mitochondrial respiratory-chain function.1 The result supports a narrow mechanistic CoQ10-Coa6 pathway under neuronal mitochondrial dysfunction while leaving human memory-supplement claims untested. Research Highlights Working memory improved in a mouse …
A 2025 Science Advances mouse study found a more brain-dependent metformin mechanism than the usual liver-gut framing suggests: low-dose metformin lost its glucose-lowering effect when brain Rap1 signaling could not be reduced, and 36 of 47 ventromedial-hypothalamus SF1 neurons responded directly to metformin.1 Research Highlights Low-dose metformin needed brain Rap1: Control mice lowered glucose after …
A 2022 Nature Communications study used non-contrast 3D T2-FLAIR magnetic resonance imaging (MRI) to map human brain lymphatic signals in living people, including apparent channels from cranial nerves and skull-base structures toward cervical lymph nodes. Research Highlights Non-contrast MRI visualized lymphatic-like brain drainage: Albayram et al. identified dorsal dural signals near venous sinuses and ventral …
A 2026 medRxiv preprint involving 65 early subacute stroke survivors found that a composite cerebral small-vessel disease MRI score predicted 90-day cognitive recovery more reliably than any single input marker.1 Lower baseline burden predicted higher follow-up Montreal Cognitive Assessment scores (β = −0.19; p = 0.009) and remained associated after baseline cognition was included (β …
A 2026 mouse study found that complete IL-6 deficiency worsened motor dysfunction and dopaminergic injury in MPTP and alpha-synuclein A53T Parkinson’s disease models, with earlier and broader vulnerability in female knockout mice.1 The result cuts against a simple “less inflammation is always better” frame: recombinant IL-6 partly improved MPTP-induced motor dysfunction and striatal dopaminergic terminal …
A 2026 mouse circuit study found that restraint stress progressively reduced medial prefrontal social coding: mPFC excitatory-neuron transient rates fell to roughly 70-80% of baseline after acute stress and nearly 50% after chronic stress, while suppressing either basolateral-amygdala input or hypothalamic oxytocin input restored social discrimination and behavior.1 The result is a circuit-specific oxytocin finding, …