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Paxil Poop Out Symptoms: Does Paroxetine Stop Working?

Paxil “poop out” refers to when someone is taking Paxil (Paroxetine) for a period of time with success and it all of a sudden stops working or “poops out.” This can result in a lot of discomfort as well as an increase in symptoms that caused the person to initially go on Paxil. When I was initially prescribed Paxil, it worked great for treating my social anxiety and depression. However after a period of about 8 months, the drug stopped working and I was left with no relief from the drug.

Many people take Paxil and other antidepressants for years before they experience some sort of “poop out.” And some people are able to tolerate taking these medications for life without any “poop out” or decrease in overall effectiveness. It all depends on the person taking the medication and their unique physiology and experience.  Some people have reported taking it for over a decade before they experienced a “poop out” while others like myself experienced one within the first year of being medicated.

Paxil Poop Out Symptoms

There are a variety of symptoms that people experience during the “poop out” phase. My hypothesis is that “poop out” is caused by the SSRI medication altering the serotonin system in the brain. This is why when one medication poops out, many times an individual will try an array of other SSRI’s and experience no relief from symptoms – it is likely because all of the benefit was used up by the first medication.

  • Anxiety spikes: When Paxil is working, it tends to do a great job at reducing symptoms of anxiety. When it stops working a person may experience increases in anxiety and/or panic attacks. In my experience while Paxil was working, it managed my anxiety to a level that allowed me to socialize and actually experience life. When it stopped working, the anxiety became so severe that I retreated back into my shell.
  • Feel very depressed: Most people notice that when Paxil stops working, they feel depressed again. In other words, their depression comes creeping back even though they are on medication. In some cases, the depression may feel even more intense and extreme than pre-Paxil. In my experience it was very difficult to cope with the depression I felt when this medication stopped working.
  • Mood swings: You may notice that your mood swings a lot following Paxil poop out. Not only will you become frustrated with the fact that the drug isn’t working, you aren’t getting any relief from symptoms. This may cause you to feel angry, aggressive, and may really make you feel deflated. While it was working your life was good, and then you get thrown out into a harsh reality where it doesn’t work.
  • Side effects: During the poop out phase, unfavorable side effects can become more prominent and noticeable. For example you may now notice that you have a headache all the time or that you feel irritable more often. Additionally you may feel dizzy or just uncomfortable because you aren’t finding the medication effective anymore.

What doctors will do when Paxil poops out…

If your Paxil stops working, most doctors will increase the dosage. Like any drug, people build up tolerance to antidepressants. Just because they are not illicit drugs doesn’t mean that people can’t build up a tolerance or have horrible withdrawals. If your Paxil stops working, a doctor will probably bump up the dosage to the next highest available increment. So if you are at 10 mg, your doctor may bump you up to 20 mg. If you are at 20 mg, your doctor may bump you up to 40 mg.

The problem with increasing like this is that you are essentially doubling the dosage of Paroxetine. For most individuals, the dose doesn’t need to be doubled. Rather the dose needs to be increased in smaller increments such as either 2.5 mg or 5 mg. A gradual upwards titration could be conducted to determine the effectiveness of a dose that is 2.5 mg more than the current dose, as well as a 5 mg increase.

If that doesn’t work, continue titrating upwards until a person experiences relief. If the upwards titration doesn’t work and or produces a worsening of side effects, it is recommended to simply withdraw from the medication altogether. Certain SSRI’s just end up losing their effectiveness after awhile.

What causes Paxil to stop working? Tolerance + CNS Changes

There are a variety of different factors that could potentially cause Paxil to stop working. My guess is that it has something to do with tolerance as well as changes to the nervous system. Paxil is known to change the way our nervous system works – causing slowed metabolism and fatigue. It has a different impact on everyone that takes it, but in general people take it for awhile, the drug changes them, and they no longer get relief.

  • Changes: Taking antidepressants like Paxil for an extended period of time is thought to lead to “poop out.” The drug changes the way your brain works, the hormones in your body, and levels of various neurotransmitters. If you take Paxil for a long period of time, it will have changed you into a different person than you were when you first started taking it.
  • Dependence: Some people can become dependent on Paxil for everyday functioning. This is similar to an alcoholic drinking every day and relying on alcohol for functioning or a person taking Adderall to perform well on the job. Eventually the consistent usage of the drug is going to catch up with the person – causing them to get no relief from the drug.
  • Neurotransmitter levels: It is hypothesized that SSRI’s like Paxil cause your neurotransmitter levels to drop over the long term. Your brain becomes accustomed to receiving the Paroxetine dose each day and this inhibits the reuptake of serotonin. Eventually your neurotransmitters will compensate for the drug – causing it to have less effect or no effect at all.
  • Physiology: Certain people have a different response to taking Paxil. In some people the drug works pretty well for years and they experience no poop out. Others take it for less than a year and the antidepressant and anxiolytic effect tends to wear off. In my experience, Paxil was effective for about 8 months and it suddenly “pooped out” and stopped working.
  • Tolerance: When Paxil stops working, a person tends to have built up a tolerance. If it initially was effective, it may just be that your brain and nervous system has become so accustomed to the medication, that it no longer does anything for you.

Does Paxil “poop out” mean the drug will never work again?

Just because Paxil poops out and stops working doesn’t mean that it will never work again. You need to give your brain and body time to recover from this drug. If it stops working, I would recommend staying off of it for at least a year before trying it again. In my experience, this is similar to a drug user building up tolerance to their drug of choice and then wondering why it stops working at the same dose. It is because they have built up a physiological tolerance to the substance that they are taking.

Although most people will not want to try Paxil after they experience the hellacious withdrawal symptoms associated with coming off of this drug, this may be the only effective medication for some.  Read more about my experience quitting Paxil cold turkey. In my experience it was the only SSRI that I responded to for social anxiety and depression. After I was on Paxil I tried all of the popular SSRI and SNRI’s and never found any sort of relief as I did while on Paxil. Just like coming off of alcohol or other drugs, you need to let your body reset itself back to homeostasis.

I believe that once homeostasis is achieved (e.g. how you felt pre-Paxil), that it will work again. In my experience I stayed off of it for over 6 years, tried it again and found it to work towards reducing anxiety and depression symptoms. Don’t get discouraged if this medication doesn’t work again for awhile. After you are on one SSRI for awhile, your serotonin system becomes altered and needs a lengthy detoxification period before it is properly reset.

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5 thoughts on “Paxil Poop Out Symptoms: Does Paroxetine Stop Working?”

  1. I 100% agree with the author of this article. I have been on 30 mg of paxil for exactly 8 months. It’s prescribed to me for PTSD & social anxiety. The last few weeks I started sleeping up to 15 hours a night & I also experienced higher than normal social anxiety.

    I couldn’t figure out what it was then I remembered I was on Paxil years ago & my doctor weaned me off after 6 months. I started cutting my Paxil in half last week & I have already begun to feel better. No more sleeping until 3 PM no more social anxiety.

    Not sure if I will wean completely off at this point or continue taking half a dose. Thank you for this article. I hope many people read it and talk to their MD if they are experiencing these symptoms. Great article & nice safe suggestions.

  2. I am currently on 37.5 mg of Paxil once a day. I started at 12 mg 6 years ago, totally dependent on it now. Tried quitting twice, was the worst experience ever! I will NOT quit taking it again, I’m okay with taking it for life, however it’s not working as well lately. I am incredibly depressed and having massive mood swings, not sleeping either.

    So I guess I will need to have it increased. I have made peace with having to be on meds for life, I think when people get so upset about being on meds it makes their life all that much harder. Just accept you need meds, it’s no big deal. If you had diabetes or a heart condition you’d take meds, right? This is no different.

    • Beth, I know this is an older thread, but you just described me to a T! Paxil wasn’t working as good for me after being on it for 20 years, I tried getting off of it twice with the help of my therapist, but the withdrawal symptoms are just to much for me.

      So I’m still on it and I’m feeling depressed and mood swings too. It’s so frustrating. What dose are you at now? And how are you doing now?

  3. My big problem happened about 5 years ago. I have been on the drug for about 10 years. My system is so high strung that I was using it as a way of reducing the amount of fight or flight chemicals that flow through my body. I had a poop out about 5 years ago. 20 mg always worked and then stopped.

    Then I went to 30 without much relief and then 40 mg. Fairly high for me although well within the therapeutic window. I am looking for a substitute for the drug to wean off it a bit or reduce dependency. I see Xanax was used by one person. I have heard this is good. Any other recommendations?

  4. I recommend cutting back 5 ml’s every three nights to every other night to permanent over a 3-4 month period, it won’t be comfortable… once you get down a complete 10 milligrams over 6 month period you can crank it up 5 again if needed. Sometimes consistently taking Paxil has backfired on me, I feel like its actually much more effective when your forgetful and you don’t take it on a regular basis perhaps allowing your body to compensate and run your system here and there is a good thing. When I’m less anxious I like to go 3-4 days without a dose sometimes so I can actually enjoy my thousand, if you get the gist. A great backup to have is a very low dose of Xanax to help bridge the changes until you can get back to normal.


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