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Deep Brain Stimulation (DBS) of Nucleus Accumbens (NAc) for Treatment-Resistant Depression (4 Case Reports)

Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD) explores the cutting-edge intersection of technology and neuroscience, offering hope to those for whom traditional treatments have failed. By targeting specific brain areas, such as the nucleus accumbens, DBS attempts to modulate the underlying neural circuits associated with depression. A recent review analyzed case reports documenting significant …

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Ketamine Increases Amygdala Volume in Treatment-Resistant Depression (TRD) (2024 MRI Study)

Depression is a complex mental health condition that significantly affects an individual’s emotional and physical well-being. Recent advances in neuroimaging have provided deeper insights into how major depressive disorder (MDD) alters brain structures, particularly the hippocampus and amygdala, and how treatments like ketamine can potentially reverse these changes. A new study using 3T and 7T …

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Psilocybin for Depression: Optimal Dosages for Antidepressant Effects (2023 Review)

Recent research has provided compelling evidence on the therapeutic potential of psilocybin, a naturally occurring psychedelic, in treating depression. A systematic review and dose-response meta-analysis shed light on the optimal dosage of psilocybin for depression, revealing variations in effectiveness based on patient subgroups and associated risks. Highlights: Psilocybin showed significant antidepressant effects, with optimal dosages …

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Bilateral Anterior Capsulotomy (BAC) for Treatment-Resistant Depression & OCD (2023 Case Reports)

In the relentless pursuit of effective treatments for mental disorders, neurosurgery offers a glimmer of hope where traditional methods falter. Bilateral anterior capsulotomy (BAC), a neurosurgical procedure, emerges as an option for patients with treatment-resistant depression (TRD) and obsessive-compulsive disorder (OCD), offering substantial relief with minimal side effects. Highlights: Bilateral Anterior Capsulotomy (BAC) is a …

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Esketamine Nasal Spray Effective Last Resort for Treatment-Resistant Depression (TRD)? (2023 Study)

Treatment-resistant depression (TRD) represents a significant challenge in mental health care, often leaving patients and clinicians in a difficult position after traditional treatments fail. Recent studies, including a prospective, observational study at a leading medical center, have brought new hope in the form of esketamine, a novel antidepressant. Highlights: Esketamine’s Mechanism: Esketamine, the S-enantiomer of …

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Case Report: Depression Treated with Deep Brain Focused Ultrasound (2023)

Deep brain stimulation using focused ultrasound leads to rapid remission of severe depression in breakthrough patient case study. Key Facts: Focused ultrasound targeted and suppressed hyperactive areas linked to depression. Stimulation lasted just 64 minutes yet caused depression remission for over 6 weeks. Approach is noninvasive and precisely targeted with no side effects observed. Technology …

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Vyvanse For Depression: Lisdexamfetamine As An Adjunct Treatment

Vyvanse (Lisdexamfetamine) is a drug developed by Shire Pharmaceuticals as a successor to Adderall.¬† Vyvanse was first approved for the treatment of attention-deficit/hyperactivity disorder¬† (ADHD) in 2007.¬† In 2015, Vyvanse was approved for binge eating disorder and was found to successfully minimize appetite and number of binge eating episodes per week compared to a placebo. …

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