Mental Health DailyResearch. Evidence. Perspective.Published research on striatum.
A 53-study resting-state functional magnetic resonance imaging (fMRI) meta-analysis found substance use disorder (SUD) linked to altered connectivity across prefrontal, striatal, thalamic, c…
Read articleRestless legs syndrome (RLS) and opioid-withdrawal restlessness both produce night-worsening urges to move. A 2026 npj Parkinson’s Disease mouse study tied that overlap to hypersensitive str…
Read articleChronic stress is a candidate mechanism for both depression and addiction risk. A 2026 mouse study found that 28 days of unpredictable chronic mild stress increased striatal dopamine D1 rece…
Read articleA 2026 resting-state fMRI study of 800 adults found intra-thalamic hypoconnectivity across schizophrenia, bipolar disorder, and major depression, but schizophrenia showed far broader subcort…
Read articleA 2026 fMRI study of 84 medication-free adolescents found that reward uncertainty had its own phase-specific brain pattern: anxiety, depression, and anhedonia separated across different task…
Read articleThe dopamine hypothesis of schizophrenia is the field’s longest-running mechanistic story, and most of its supporting evidence has been cross-sectional. A 2026 longitudinal PET study by Schu…
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