lysosomes

Published research on lysosomes.

Neurodegenerative DiseasesJul 11, 2026

PINK1 and Parkin Link Parkinson’s Disease to Failed Mitochondrial Cleanup

A 2026 review ties the Parkinson’s disease genes PINK1 and parkin to damaged-mitochondria cleanup, from damage sensing and ubiquitin tagging to autophagy recruitment and lysosomal degradatio…

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Neurodegenerative DiseasesJun 27, 2026

TMEM175 Proton Channel Finding Clarifies Parkinson’s Lysosome Risk

A 2026 PNAS study found that TMEM175 behaves as a pH-sensitive lysosomal channel relevant to Parkinson’s risk biology.1 Acidifying the luminal side from pH 7.4 to 4.7 activated proton conduc…

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Neurodegenerative DiseasesJun 6, 2026

NDST3 Suppression Restores Lysosome Acidity in Alzheimer’s Mouse Models

A 2026 mechanistic Alzheimer’s study found that suppressing NDST3 shifted lysosomal pH in APP695Swe neuronal cells from 5.6 back below 5.0, then reduced amyloid-β, MAPT/tau pathology, neuron…

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