MentalHealthDaily

Prolonged Antidepressant Effect of Ketamine: NMDA Receptors & Lateral Habenula “Trapping”

by GLOOM

Ketamine causes rapid and sustained antidepressant effects that last longer than its presence in the body. This is due to ketamine getting trapped and accumulating in NMDA receptors, causing prolonged neural inhibition. Manipulating brain activity can shorten or extend ketamine’s effects. Highlights: Ketamine continues blocking NMDA receptors for 24 hours despite rapid elimination from plasma …

Advanced OCD Treatment Strategies & New Drugs Under Investigation (2023)

by GLOOM

OCD affects approximately 1-3% of the population and often begins in childhood or adolescence. While OCD was previously considered untreatable, advances in the past few decades have led to effective evidence-based treatments. Key Facts: Glutamatergic medications like memantine, ketamine, and N-acetylcysteine have shown preliminary evidence of efficacy in small trials, but larger studies have been …

Taking Lamictal (Lamotrigine) For Anxiety Disorders: Does It Help?

by GLOOM

Lamotrigine is a synthetic phenyltriazine chemical with anticonvulsant and analgesic properties initially sold by GlaxoSmithKline under the brand name Lamictal. It was first approved by the FDA in 1994 for the treatment of partial seizures in adults, and was subsequently approved in 1998 for the management of Lennox-Gastaut syndrome – a severe form of epilepsy …

Magnesium For Depression: An Underexplored Treatment

by GLOOM

Magnesium is regarded as an essential mineral for humans and functions as a cofactor in upwards of 300 biochemical processes throughout the body. For example, magnesium is implicated in: ATP production, blood pressure regulation, bone development, glucose modulation, heart rhythm normalization, muscle and nerve function, plus protein synthesis. Knowing that magnesium is essential for optimal …

5 Oxaloacetate Benefits: How Supplementation Protects Your Brain & General Health

by GLOOM

Oxaloacetate (or Oxaloacetic Acid) is an organic compound that is involved in many neurophysiological processes within your body. It plays a key role in functions such as: amino acid synthesis, citric acid cycle, fatty acid synthesis, gluconeogenesis, glyoxylate cycle, and the urea cycle. For example, oxaloacetate is considered an intermediate in the Kreb’s cycle prior …

5 New NMDA Receptor (Glutamate) Modulators For Depression

by GLOOM

Scientists and mental health researchers have long been collecting evidence to discover what causes depression. Their goal is to find a specific neurotransmitter or system that could be targeted to develop a new class of antidepressant medication that would be more effective for the masses, result in less side effects, and be considered safe. While …

New Antidepressant GLYX-13 (Clinical Trials): Partial NMDA Receptor Agonist

by GLOOM

A new antidepressant chemically named “GLYX-13” was developed by the biotech company Naurex for individuals with treatment-resistant depression. It is currently in clinical trials as an antidepressant augmentation strategy, meaning it is used as an add-on to already approved treatments. However, most evidence would suggest that it works extremely well as a standalone treatment option. …