Mental Health DailyResearch. Evidence. Perspective.Published research on glutamate.
In a 2026 study of 48 male rats with fear-conditioned anxiety, 10 days of schisandrin B at 10 or 20 mg/kg increased time in the open arms of an elevated plus maze, similar to diazepam, but n…
Read articleCocaine relapse circuitry looks different when alcohol is part of the history. In a rat model, inhibiting prelimbic cortex neurons projecting to the nucleus accumbens core blocked cue-trigge…
Read articleA 2026 medRxiv preprint did not find one simple autism excitation-inhibition signature. Bertelsen et al. found 2 EEG-derived E:I neurosubtypes in 286 autistic males: a 47% inhibition-dominan…
Read articlePTSD and major depressive disorder co-occur in roughly half of patients with either diagnosis, and the comorbid presentation is more severe than either alone. The mechanistic question has be…
Read articleQuetiapine, a second-generation antipsychotic medication, is renowned for its efficacy in managing a spectrum of psychiatric conditions, including schizophrenia, bipolar disorder, and major …
Read articleAttention-Deficit Hyperactivity Disorder (ADHD) is a complex neurodevelopmental condition that has puzzled researchers and clinicians for decades. Recent studies have begun to unravel the in…
Read articleThe journey to overcome addiction is fraught with challenges, not least due to the limited options available for pharmacological intervention. In recent research, the focus has shifted towar…
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