MentalHealthDaily

Entorhinal Dopamine Fails Early in Alzheimer’s Mice

by GLOOM

Editorial card showing the lateral entorhinal cortex with dopamine projections from the midbrain, illustrating an early-Alzheimer's mechanism finding rescued by L-DOPA in mice.

A 2026 Nature Neuroscience study from the Igarashi lab proposes a circuit-level answer for why the lateral entorhinal cortex (LEC) is the first cortical region to falter in Alzheimer’s: dopamine inputs from the VTA and substantia nigra to the LEC go functionally silent at the earliest disease stage in an APP knock-in mouse — before …

Human Memory Context Neurons: 3,109-Cell Study in Epilepsy Patients

by GLOOM

MHD featured image for human memory context neurons and hippocampal item-context coding.

A 2026 Nature single-neuron study recorded 3,109 medial temporal lobe neurons from 16 neurosurgical epilepsy patients and found that human item-context memory mostly used separate item and context populations: 597 stimulus-modulated neurons, 200 context-modulated neurons, and only 50 neurons that encoded specific picture-question combinations.1 The result argues against a simple “one cell stores the whole …