MentalHealthDaily

Mitophagy & Depression: Mitochondrial Autophagy as an Antidepressant Target?

by GLOOM

Depression is a pervasive mental health issue with complex origins and often inadequate treatment options. Recent studies have suggested that mitophagy, the process of selective mitochondrial autophagy, plays a crucial role in the onset and progression of depression, offering new insights into its pathogenesis and potential treatments. Highlights: Major Depressive Disorder (MDD) affects millions globally, …

Zembrin® (Sceletium tortuosum) for Anxiety & Depression: Testing Alkaloid-Specific Effects (2023 Study)

by GLOOM

Sceletium tortuosum (ST) Extract, known as Zembrin®, is a traditional South African remedy was recently evaluated for its nuanced effects on anxiety and depression through a unique study using zebrafish larvae. Highlights: Zebrafish Larvae as Model Organisms: A study used zebrafish larvae to observe Zembrin®’s anxiolytic & antidepressant-like effects, offering a detailed and dynamic understanding …

Considering Lactate in Psychiatric Disorders & Drug Development (2023 Review)

by GLOOM

Lactate, traditionally viewed as a simple metabolic byproduct, is emerging as a significant player in the realm of psychiatric disorders. Recent research reveals its intricate role as both an energy source and a signaling molecule, potentially influencing a wide array of mental health conditions. Highlights: Shift in Lactate Perception: The review highlights a paradigm shift …

Best Antidepressants for Preventing Depression Relapse & Maintenance Treatment (Study)

by GLOOM

Depression is a complex, often long-term condition requiring careful management. Recent research has shed light on the effectiveness of various antidepressants during the maintenance phase of major depressive disorder (MDD). Highlights: Extensive Study: The meta-analysis included 34 double-blind, placebo-controlled trials with a total of 9,384 participants. Multiple Drugs Analyzed: 20 different antidepressants were compared for …

Prolonged Antidepressant Effect of Ketamine: NMDA Receptors & Lateral Habenula “Trapping”

by GLOOM

Ketamine causes rapid and sustained antidepressant effects that last longer than its presence in the body. This is due to ketamine getting trapped and accumulating in NMDA receptors, causing prolonged neural inhibition. Manipulating brain activity can shorten or extend ketamine’s effects. Highlights: Ketamine continues blocking NMDA receptors for 24 hours despite rapid elimination from plasma …

NLRP3 Inflammasome & Depression: A Target for Antidepressant Development?

by GLOOM

The NLRP3 inflammasome stands at the crossroads of immune response and mental health, playing a pivotal role in the inflammatory processes implicated in depression. Researchers are exploring the intricate relationship between NLRP3 activation and depressive disorders, highlighting the potential for innovative treatments targeting this complex molecular pathway. Highlights: NLRP3 Inflammasome Activation: NLRP3, a component of …

Elevated Mitochondrial DNA (mtDNA) Levels Linked to Depression (Possible Diagnostic Biomarker)

by GLOOM

New research reveals that individuals with depression exhibit significantly higher levels of mitochondrial DNA (mtDNA) compared to healthy individuals. This suggests mtDNA could serve as a promising biomarker to improve depression diagnosis and treatment outcomes. Key facts: Meta-analysis of 12 studies with 1400 participants shows elevated mtDNA levels in blood and skin cells of depressed …