A 2026 ALSPAC analysis tested a narrow claim behind routine genetic screening for childhood attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD): whether rare copy number variants (CNVs; deleted or duplicated DNA segments) make young-adult outcomes worse than ADHD/ASD status alone would predict. In 8,414 people with usable CNV data, ADHD and ASD predicted worse …
A 2026 fMRI meta-analysis of 11 studies found a narrow anxious-depression signal: 829 anxious-depression patients differed from 681 non-anxious MDD patients in left middle temporal gyrus activation (SDM-Z = 2.046, p = 0.020), while healthy-control contrasts centered on the anterior commissure and right middle frontal gyrus. The calibrated interpretation is not “amygdala and insula hyperactivity …
A 2026 fMRI study of 84 medication-free adolescents found that reward uncertainty had its own phase-specific brain pattern: anxiety, depression, and anhedonia separated across different task phases and brain systems.1 The clearest clinical split was narrow but useful: anxiety tracked blunted striatum/thalamus activation during uncertain non-reward expectancy, while depression and anhedonia tracked higher visual/default-network activation …
A 2026 UK Biobank MRI preprint involving 71,214 adults found that chronic pain plus current depression had a structural brain profile that was more than chronic pain plus depression pasted together. The 1,377-person comorbid group showed widespread lower cortical volume, lower bilateral thalamic and hippocampal volume, lower left accumbens volume, and broad white-matter microstructure differences …
Iceland is a registry-rich country with a small enough population that genuinely nationwide health data is feasible — not the survey-based approximations that anchor most psychiatric epidemiology elsewhere. A 2026 PLOS One study used the Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM) cohort — 80,759 adults aged 40+, representing 54% of all eligible Icelanders …
Children with intellectual disability are 3–4x more likely to have a comorbid psychiatric disorder than peers without ID. A 2026 nationwide Korean study by Joo and colleagues tracks how those rates changed across a decade.1 Research Highlights Korean children and adolescents (ages 2–18) with intellectual disability had ADHD comorbidity rise from 30.2% in 2012 to …
Psychedelic-assisted therapy has been one of the most-covered mental-health stories of the past decade. A 2026 quantitative analysis by Evers and colleagues maps how media enthusiasm grew, peaked, and partially pulled back across major U.S. outlets — and how the coverage related to the actual evidence base for depression and PTSD.1 Research Highlights Psychedelic clinical …