MentalHealthDaily

Cognitive Function Does Not Predict Response to tDCS for Depression (2023 Trial)

Transcranial Direct Current Stimulation (tDCS) has been explored as a potential treatment for major depressive disorder (MDD), particularly for patients who have not responded to traditional treatments like selective serotonin reuptake inhibitors (SSRIs). This non-invasive technique involves applying a weak electrical current to the prefrontal cortex of the brain, aiming to modulate neurocognitive functions. However, …

Tramadol for Depression: Highly Effective as Off-Label Antidepressant (According to User Reviews)

by GLOOM

Tramadol, commonly known for its pain-relieving properties, has emerged as an effective off-label treatment for depression according to patient experiences and reviews. A recent analysis of tramadol’s antidepressant potential examined user feedback – comparing its efficacy and safety with established antidepressants. It considered the perspectives of patients who have found relief from depression with tramadol, …

Are Mystical Experiences Required for the Antidepressant Effects of Ketamine & Psychedelics?

by GLOOM

The intersection of mental health treatment and pharmacology is witnessing a remarkable shift with the growing interest in ketamine and classic psychedelics like psilocybin for their rapid and sustained antidepressant effects. Unlike traditional antidepressants, these substances offer hope for those with treatment-resistant depression by potentially transforming treatment paradigms. However, it remains somewhat unclear as to …

Tianeptine Trends in the U.S.: Antidepressant, Nootropic, Street Drug (“Gas Station Heroin” & ZaZa)

by GLOOM

Tianeptine is an atypical antidepressant that has been approved in several countries for treating depression but is not authorized for medical use in the United States. Despite this, it has found a significant market in the U.S. as a nootropic, often sold under names like ZaZa or Tianna Red, and has been nicknamed “gas station …

Empagliflozin for Depression: Effective Adjunct with SSRIs (2024 Clinical Trial)

by GLOOM

Major Depressive Disorder (MDD) impacts millions globally, making it a significant public health challenge. Traditional treatments like Selective Serotonin Reuptake Inhibitors (SSRIs) don’t work for everyone, highlighting the need for innovative approaches. Recent clinical trials exploring the use of empagliflozin, a medication originally used to lower blood sugar in diabetes patients, have shown promising results …

Melatonin Phases & Circadian Rhythms vs. Depression & Anhedonia Severity (2024 Study)

by GLOOM

In the intricate world of mental health, the rhythms of our body’s natural processes play a pivotal role, particularly the circadian rhythm of melatonin, a hormone primarily produced by the pineal gland. Recent research suggests that variations in melatonin’s circadian rhythm might not only distinguish between depression and bipolar disorder but also correlate with the …

EPA & DHA Treat Depression in Mouse Models of Ulcerative Colitis (UC) (2024 Study)

by GLOOM

Recent research has uncovered significant insights into the intersection of physical and mental health, particularly focusing on the relationship between ulcerative colitis (UC) and depression. This study has delved into how two omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can alleviate depressive-like behavior in mice induced by UC. Through meticulous experimentation, it …