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cognitive impairment

Abnormal EEG Microstates Linked to Major Depression & Related Cognitive Impairment (2024 Study)

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In the quest to understand the enigmatic nature of depression, scientists are turning to the intricate patterns of brain activity, seeking clues hidden within the electrical storm of thoughts and emotions. By examining electroencephalography (EEG) microstates—brief, recurring patterns of brain activity—researchers have begun to piece together how depression alters the fundamental dynamics of the brain. …

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Electroconvulsive Therapy (ECT) & Long-Term Cognitive Effects in Major Depression (2023 Review)

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Electroconvulsive therapy (ECT) has long been a controversial yet potent treatment for major depressive disorder (MDD), particularly in cases resistant to conventional therapies. Despite its effectiveness, the long-term cognitive effects of ECT have been a subject of intense debate. A recent meta-analysis offers new insights into these cognitive changes, shedding light on the nuances of …

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Antidepressants & Dementia Risk in Elderly Users: SSRIs vs. TCAs (2024 Study)

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Recent research has uncovered connections between the use of antidepressants and the risk of developing dementia in the elderly. This complex relationship, marked by varying results and considerations, is becoming a critical area of study in geriatric medicine and mental health. In light of these findings, it is crucial to delve into the nuances of …

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Semaglutide & Empagliflozin May Treat Obesity-Related Cognitive Impairment (Mouse Study)

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Obesity now affects over 650 million adults globally and is a major risk factor for various chronic diseases including cognitive decline and impairment. Recent evidence shows a link between obesity, reduced brain volume and neuronal loss, increased dementia risk, and impaired learning, memory and cognition. Preliminary evidence suggests that weight loss drugs like semaglutide may …

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Long COVID Brain Fog & Cognitive Deficits Linked to Specific Biomarkers

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A large prospective study has uncovered two blood biomarker profiles measured during acute COVID-19 that are associated with cognitive deficits months later. Higher fibrinogen and lower C-reactive protein predict both objective and subjective cognitive impairment. Higher D-dimer and lower C-reactive protein predict subjective deficits and occupational impact. Key Facts: In 1,837 COVID-19 patients, two acute …

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Long Term Effects of Modafinil: Hypothetical Risks & Rewards

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Modafinil (brand name “Provigil”) is a blockbuster eugeroic drug synthesized by Cephalon Pharmaceuticals (now Teva) and approved in 1998 for the treatment of excessive daytime sleepiness (EDS) associated with narcolepsy.  It was since approved for the treatment of excessive daytime sleepiness associated with obstructive sleep apnea, as well as to normalize circadian rhythms in diagnoses …

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