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Repetitive TMS for Alzheimer’s Disease Alters Brain Waves & Enhances Cognition (2024 Study)

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Repetitive transcranial magnetic stimulation (rTMS) is making waves in the field of Alzheimer’s disease (AD) research, offering a glimmer of hope for enhancing cognitive functions in patients. By targeting specific brain regions, rTMS has shown promising results in modulating neural activity and improving cognitive scores. This innovative therapy, coupled with real-time monitoring through electroencephalography (EEG), …

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Gene Editing with CRISPR/Cas9 to Treat Corticosteroid-Induced Neuropsychiatric Disorders (2023 Review)

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The widespread use of corticosteroids (CCSs) across the globe for treating inflammatory conditions has led to an increased incidence of corticosteroid-induced neuropsychiatric disorders (NPDs), raising significant public health concerns. These disorders range from depression and anxiety to severe cognitive changes, challenging the medical community to find effective treatments. The exploration of genetic and epigenetic factors …

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Effect of A Short Nap on Cognitive Function & Brain Connectivity with Sleep Deprivation (2023 Study)

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Sleep deprivation (SD) is a common issue in today’s fast-paced world, leading to temporary cognitive impairments that can significantly affect daily functioning. However, new research reveals that even a short nap following a period of SD can help reverse these impairments to some extent, shedding light on the brain’s remarkable ability to recover. Highlights: Cognitive …

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PGAM5 Genetics & Depression via ATP Levels in the Prefrontal Cortex (2023 Mouse Study)

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Major depressive disorder (MDD) is a complex and prevalent psychiatric condition that affects millions worldwide, yet its underlying mechanisms remain only partially understood. Recent research sheds light on the critical roles of phosphoglycerate mutase family member 5 (PGAM5) and adenosine triphosphate (ATP) in the brain, offering new insights into how disruptions in energy metabolism can …

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GW043 as Rapid Antidepressant: Partial Agonist of NMDA Receptors (2024 Study)

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GW043 emerges as a promising new compound in the treatment of depression showcasing rapid and significant antidepressant effects by targeting NMDA receptors (NMDARs). This mechanism offers hope for those suffering from depression and sheds light on the intricate mechanisms of synaptic plasticity and neurogenesis that underpin GW043’s therapeutic benefits. Highlights: GW043’s Mechanism of Action: GW043 …

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Berberine for Depression: Mechanisms & Antidepressant Effects (2024 Review)

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Depression, a pervasive global health issue, significantly impairs quality of life and burdens the healthcare system. Despite the availability of numerous antidepressants, their effectiveness is often limited, pushing researchers to explore alternative treatments. Berberine, a natural compound with a diverse pharmacological profile, has shown promising antidepressant effects, offering a potential complementary or alternative approach to …

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Targeting the Nucleus Accumbens D1-MSN cAMP for Depression & Crocin’s Rapid Antidepressant Effect (2024 Study)

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Depression, a debilitating mental health disorder, has long puzzled scientists and clinicians alike. Recent research sheds light on the nucleus accumbens (NAc), a brain region associated with reward and pleasure, highlighting its critical role in the pathophysiology of depression. Specifically, the study shows how manipulating cyclic adenosine monophosphate (cAMP) levels within dopamine D1 receptor medium …

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