A 2026 community survey of 945 older adults in Nepal's Far-Western Sudurpaschim Province found geriatric depression in 43.9% of participants and a strong inverse link between depression scores and quality of life. The clearest adjusted predictors were age 75 or older and hill-region residence, while income and sex weakened after multivariable adjustment.1 Research Highlights Depression …
A 2022 Nature Communications study used non-contrast 3D T2-FLAIR magnetic resonance imaging (MRI) to map human brain lymphatic signals in living people, including apparent channels from cranial nerves and skull-base structures toward cervical lymph nodes. Research Highlights Non-contrast MRI visualized lymphatic-like brain drainage: Albayram et al. identified dorsal dural signals near venous sinuses and ventral …
Coffee is widely framed as cognitively friendly, but a 2026 prospective study from Boscaini et al. published in Nature Communications used shotgun metagenomics, metabolomics, and cognitive testing in 62 healthy adults to show that coffee drinkers and non-coffee drinkers differ on the gut microbiome, key neurotransmitter-related metabolites, and behavioral measures — with coffee drinkers showing …
GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide) act on the brain as well as the gut, and a 2026 real-world cohort study from Kamel-Abusalha et al. propensity-matched 118,993 GLP-1 RA users to 118,993 non-users in the TriNetX network and found a modest but statistically robust 21–23% higher hazard of new-onset hypersomnolence at 1 and 5 years.1 …
Resting-state fMRI studies of postpartum depression have produced inconsistent results for years. A 2026 voxel-based meta-analysis pooled 12 studies of 475 patients and found 4 reliable regional differences (amygdala, precuneus, occipital, precentral cortex) at uncorrected thresholds, none of which held up under strict family-wise error correction.1 Research Highlights 12-study fMRI pool: Chen et al. analyzed …
A 2026 medRxiv preprint involving 65 early subacute stroke survivors found that a composite cerebral small-vessel disease MRI score predicted 90-day cognitive recovery more reliably than any single input marker.1 Lower baseline burden predicted higher follow-up Montreal Cognitive Assessment scores (β = −0.19; p = 0.009) and remained associated after baseline cognition was included (β …
A 2026 mouse study found that complete IL-6 deficiency worsened motor dysfunction and dopaminergic injury in MPTP and alpha-synuclein A53T Parkinson’s disease models, with earlier and broader vulnerability in female knockout mice.1 The result cuts against a simple “less inflammation is always better” frame: recombinant IL-6 partly improved MPTP-induced motor dysfunction and striatal dopaminergic terminal …