A 2025 Science Advances mouse study found a more brain-dependent metformin mechanism than the usual liver-gut framing suggests: low-dose metformin lost its glucose-lowering effect when brain Rap1 signaling could not be reduced, and 36 of 47 ventromedial-hypothalamus SF1 neurons responded directly to metformin.1 Research Highlights Low-dose metformin needed brain Rap1: Control mice lowered glucose after …
A 2026 longitudinal study found reassuring cognitive trajectories after mild-to-moderate COVID-19: Alpha/Delta and Omicron groups both improved by follow-up, and neither group showed persistent neuropsychological test deficits vs. population norms. Psychiatric symptoms and fatigue were also broadly similar across variants.1 Research Highlights 55 adults were assessed: 27 were infected during the Alpha/Delta era and 28 …
Daytime agitation in dementia fluctuates day-to-day, and a 2026 explanatory study from Liu et al. used contactless under-mattress sensors in 55 long-term-care residents and an external 17-person home-monitoring cohort to show that lower nocturnal respiratory rate and higher activity instability robustly predict next-day agitation occurrence — but not severity.1 Research Highlights Lower breathing rate: adjusted …
A 2026 behavioral-variant frontotemporal dementia MRI study found that simple visual ratings of orbitofrontal and frontoinsular brain atrophy helped separate probable from possible bvFTD, with baseline left orbitofrontal atrophy predicting 3.77-fold higher odds of probable bvFTD classification.1 Research Highlights 143 people were rated: the study included 93 probable bvFTD cases, 15 possible bvFTD cases, and …
A 2026 survey of 467 University of Sydney undergraduate psychology students found that participants generated more and more accurate observable cues for alcohol intoxication than for cannabis intoxication.1 When unanswered cue fields were counted, accurate alcohol cues appeared in 63.2% of possible response slots, while accurate cannabis cues appeared in 37.3%. Research Highlights Alcohol cues …
A 2026 community survey of 945 older adults in Nepal's Far-Western Sudurpaschim Province found geriatric depression in 43.9% of participants and a strong inverse link between depression scores and quality of life. The clearest adjusted predictors were age 75 or older and hill-region residence, while income and sex weakened after multivariable adjustment.1 Research Highlights Depression …
A 2022 Nature Communications study used non-contrast 3D T2-FLAIR magnetic resonance imaging (MRI) to map human brain lymphatic signals in living people, including apparent channels from cranial nerves and skull-base structures toward cervical lymph nodes. Research Highlights Non-contrast MRI visualized lymphatic-like brain drainage: Albayram et al. identified dorsal dural signals near venous sinuses and ventral …