A 2026 hospital MRI study found that the left paracingulate sulcus was present in 31 of 109 catatonia patients (28%) vs. 171 of 323 psychiatric controls without catatonia (53%), a left-hemisphere group effect that survived adjustment for age, sex, scanner, brain volume, benzodiazepines, and antipsychotics.1 Research Highlights Left PCS signal: left paracingulate sulcus (PCS) presence …
Lithium prescribing during pregnancy sits in a knot of competing risks. The teratogenicity data have been recalibrated dramatically since the 1970s, while the postpartum-relapse data have moved in the opposite direction. Most popular framing still treats lithium as a uniquely dangerous fetal exposure to be avoided when possible. The new Chauhan UK cohort shows what …
A 1.6M-participant meta-analysis shows a clear gradient: parental schizophrenia hits offspring cognition harder than bipolar, which hits harder than MDD.
Bipolar disorder (BD), a complex and multifaceted mental illness, manifests through various mood states including depression, mania/hypomania, and euthymia. Recent advances in neuroimaging, particularly resting-state functional magnetic resonance imaging (fMRI), have shed light on the intricate dynamics of brain activity underlying these mood states. A new study employing dynamic fractional amplitude of low-frequency fluctuations (dfALFF) …
Bipolar disorder (BD) remains a complex psychiatric condition with limited therapeutic options, posing a significant challenge in drug discovery. The latest research leverages network-based drug repurposing, employing advanced computational techniques to identify novel treatment strategies for bipolar disorder. Highlights: Network-based drug repurposing employs gene regulatory networks to identify potential new uses for existing drugs in …
Bipolar Disorder (BD), a complex psychiatric condition, is under constant study to better understand its pathophysiology and improve diagnostic and treatment strategies. Recent research has focused on the role of serum neurofilament light (sNfL), a marker for neuro-axonal injury, in BD. Highlights: Individuals with BD for more than three years exhibit higher sNfL levels compared …
Bipolar Disorder (BD) and Major Depressive Disorder (MDD) are two of the most prevalent mood disorders, yet they are often misdiagnosed due to overlapping symptoms. This misdiagnosis can lead to inadequate treatment and worsened patient outcomes. However, recent advances in functional magnetic resonance imaging (fMRI) offer a promising solution to this challenge. By analyzing brain …