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LY-2456302 For Depression: Kappa Opioid Receptor (KOR) Antagonist

In recent years, biotech and pharmaceutical companies have been developing new classes of antidepressants. These new classes attempt to improve on older classes of medication in regards to efficacy, side effects, and tolerability. One such class that is being developed is that which targets opioid receptors, particularly the kappa receptor. These drugs are classified as …

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2 New Kappa Opioid Receptor (KOR) Antagonists For Depression

The quest to come up with a superior antidepressant is in full effect among biotech and pharmaceutical companies. Although there are some companies that are still tweaking various formulations of serotonergic, noradrenergic, and dopaminergic substances (e.g. triple reuptake inhibitors) others are thinking outside the box. Based on current trends, the next decade or two of …

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New Antidepressant NRX-1074 (NMDA Receptor Modulator) In Development

NRX-1074 is a new antidepressant under development by the biotech company Naurex. It is this same company that has already been granted “fast track” status by the FDA for their intravenous antidepressant GLYX-13 – which shows significant promise. Naurex’s private stock has been steadily rising due to emergence of preliminary evidence suggesting that both of …

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New Antidepressant GLYX-13 (Clinical Trials): Partial NMDA Receptor Agonist

A new antidepressant chemically named “GLYX-13” was developed by the biotech company Naurex for individuals with treatment-resistant depression. It is currently in clinical trials as an antidepressant augmentation strategy, meaning it is used as an add-on to already approved treatments. However, most evidence would suggest that it works extremely well as a standalone treatment option. …

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How To Improve Psychiatric Treatment Outcomes with Technology & Variable Tracking

It’s blatantly obvious that psychiatry is an imperfect practice. These days people often seek the help of a psychiatrist with the belief that a pill can be prescribed to essentially cure a disease or get symptoms of a mental illness under control. While psychiatry can offer many benefits in the treatment of certain conditions, especially …

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Antidepressant Roulette: Switching / Trying New Medications Is Often Problematic

Many people seek out treatment for their depression from general practitioners and psychiatrists. If you have a serious mental illness that requires pharmaceutical treatment, it is generally best to work with a quality psychiatrist. Regardless of whether you seek the help of a psychiatrist or simply go to your family doctor, finding the right antidepressant …

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