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Schizophrenia and Accelerated Aging: What The Latest Research Suggests In 2026

Two parallel timelines representing chronological vs. biological age in schizophrenia: an early offset at first episode, then parallel trajectories afterward — illustrating advanced rather than accelerated aging.

Research Highlights People with schizophrenia die 15–20 years earlier on average (SMR 2.5–3.5x), develop dementia roughly 20 years earlier, and show metabolic disease in their 20s and 30s. The 2008 “accelerated aging” hypothesis was coined to explain that pattern.1,6,7 A 2026 systematic review of 170 studies argues “advanced aging” fits better than “accelerated aging,” with …

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