MentalHealthDaily

Melatonin aMT6s GWAS Found No Hits, PRS Linked to Sleep and Diabetes

by GLOOM

MHD featured image for melatonin metabolite genetics, sleep duration, and type 2 diabetes signals.

A 2026 multi-ancestry genome-wide association study of urinary aMT6s, a melatonin metabolite used as a proxy for overnight melatonin secretion, found 0 genome-wide significant loci in 11,744 people, even though 23 variants reached suggestive significance and 8 were supported by 2 analytic methods. Research Highlights No common variant dominated: the 2026 GWAS meta-analysis involving 11,744 …

Caffeine Intake and Sleep Quality: 428 Working Adults, Source by Source

by GLOOM

MHD featured image for caffeine intake, coffee and tea sources, and sleep quality in working adults.

A 2026 cross-sectional study involving 428 employed adults found that poor sleepers reported a median 292.8 mg/day of caffeine, compared with 176.1 mg/day among good sleepers, and total caffeine intake still predicted higher Pittsburgh Sleep Quality Index scores after adjustment (β = 0.147, p = 0.003). The source breakdown is the useful part: black coffee, …