Mental Health DailyResearch. Evidence. Perspective.Published research on psychosis.
A 2026 case report describes a man in his 30s with autism, childhood temporal lobe epilepsy and treatment-resistant schizophrenia whose delusions center on fictional media characters. Clozap…
Read articleA 2026 case report from Japan describes a woman in her 50s with treatment-resistant schizophrenia who was diagnosed with multiple sclerosis 31 years after her psychosis began. MS treatment s…
Read articleA 2026 ENIGMA structural MRI preprint involving 3,958 people diagnosed with schizophrenia and 5,489 controls found 2 cortical-alteration subtypes rather than 1 uniform brain pattern.1 The re…
Read articleA 2026 systematic review argues that catatonia should be read as a limbic-cortical circuit syndrome, with motor shutdown tied to brain systems for threat, salience, motivation, and emotional…
Read articleA 244-person functional MRI study found no significant evidence that ventral striatum activation during reward anticipation works as an endophenotype — a measurable trait used to connect inh…
Read articleA 2026 immunopsychiatry cohort study found that soluble CD27 (sCD27), a marker of T-cell activation, was positive in cerebrospinal fluid in 23% of severe psychiatric patients selected for su…
Read articleThe dopamine hypothesis of schizophrenia is the field’s longest-running mechanistic story, and most of its supporting evidence has been cross-sectional. A 2026 longitudinal PET study by Schu…
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