KNT-127 for Anxiety: Delta Opioid Receptor Agonist via PL-BLA Pathway (2023 Study)
Recent scientific advancements have illuminated the crucial role of the prelimbic cortex to basolateral amygdala (PL-BLA) pathway in regulating anxiety-like behaviors. Utilizing cutting-edge optogenetic techniques and selective delta-opioid receptor (DOP) agonists, researchers have begun to decode the complex neural circuitry underlying anxiety disorders. Highlights: PL-BLA Pathway Significance: The connection between the prelimbic cortex (PL) and …