fMRI Low-Frequency Oscillation Tracked Nicotine Dependence and Arousal
A 2026 multi-cohort fMRI study found that a signal often treated as physiological noise tracked nicotine dependence, cue-induced craving, abstinence, and stimulant effects.1 During cigarette cue exposure, systemic low-frequency oscillation amplitude correlated with nicotine dependence at r = −0.32, p = .009. Research Highlights Dependence tracked cue-period physiology: In 64 smokers, higher average sLFO amplitude …