A 2026 pilot randomized trial in 16 frail adults with multiple sclerosis found that 6 weeks of supervised multimodal exercise was feasible: retention was 87.5%, adherence was 97.2%, no adverse events were recorded, and fatigue and quality-of-life scores moved more than they did with waitlist control.1 Research Highlights Feasibility cleared the prespecified bar: 14 of …
A 2026 medRxiv case-control study found that serum myelin oligodendrocyte glycoprotein was 20.5 pg/ml higher in multiple sclerosis than in healthy donors and 15.3 pg/ml higher during relapse than remission, making it a plausible blood marker of demyelination rather than a replacement for neurofilament light chain. Research Highlights MOG was higher in MS: serum myelin …
A 2026 immunopsychiatry cohort study found that soluble CD27 (sCD27), a marker of T-cell activation, was positive in cerebrospinal fluid in 23% of severe psychiatric patients selected for suspected immune involvement and in 88% of multiple sclerosis patients used as a positive-control group. In the psychiatric cohort, combined cerebrospinal fluid or blood sCD27 positivity was …
Standard memory testing can tell a multiple-sclerosis (MS) patient that recall is normal after 30 minutes while missing a deficit that appears days later. Jansen et al. tested that exact blind spot in 62 MS patients and 65 matched controls: 7-day/30-minute recall ratios were lower in MS on both verbal-list recall (0.64 vs. 0.78, p …