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Solriamfetol for ADHD in Adults: A New Alternative Treatment?

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by problems with inattention, hyperactivity, and impulsivity. While ADHD has historically been considered a disorder of childhood, it is now known that symptoms frequently persist into adulthood. A new pilot study published in the Journal of Clinical Psychiatry provides the first data indicating that a newer …

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Dextromethorphan-Bupropion (Auvelity) for Depression: Clinical Trial Data for the New Rapid-Acting Antidepressant

Major depressive disorder (MDD) is a significant global health concern, affecting over 280 million people worldwide. While numerous pharmacological options exist, challenges remain in achieving timely, robust, and sustained antidepressant response. Dextromethorphan-bupropion is a novel oral antidepressant recently approved by the FDA for MDD in adults that may address some of these unmet needs. Key …

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Pantoprazole (Protonix) vs. Omeprazole (Prilosec)

Pantoprazole and Omeprazole are medications classified as proton-pump inhibitors (PPIs) and are commonly prescribed for the management of medical conditions in which stomach acid reduction is of therapeutic benefit. Chemists at Byk Gulden, a subsidiary of Altana (a German chemical company), are credited with the synthesis of pantoprazole in 1985 – whereas Swedish chemists at …

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Lexapro (Escitalopram) vs. Prozac (Fluoxetine)

Lexapro (escitalopram) and Prozac (fluoxetine) are two medications within the selective-serotonin reuptake inhibitors (SSRI) classification that are commonly administered for the treatment of neuropsychiatric disorders.  The development of Lexapro (escitalopram) was initiated in 1997 by Lundbeck and Forest Laboratories – whereas the development of Prozac (fluoxetine) was initiated in the 1970s by chemists (Bryan Molloy …

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Pregabalin (Lyrica) vs. Gabapentin (Neurontin)

Lyrica (pregabalin) and Neurontin (gabapentin) are both classified as “gabapentinoids” (i.e. α2δ ligands).  As gabapentinoids, Lyrica (pregabalin) and Neurontin (gabapentin) are chemical analogues of the inhibitory neurotransmitter GABA (gamma-aminobutyric acid) that interact with α2δ subunit-containing voltage-dependent calcium channels. Development of gabapentin (Neurontin) was initiated in the 1970s by chemists at the pharmaceutical company Parke-Davis – …

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Celexa (Citalopram) vs. Lexapro (Escitalopram): Which Is Better?

Celexa (citalopram) and Lexapro (escitalopram) are chemically-analogous medications within the selective-serotonin reuptake inhibitor (SSRI) classification that are regularly prescribed for the management of neuropsychiatric disorders.  Chemically, Celexa contains enantiomers S-citalopram and R-citalopram – whereas Lexapro solely contains S-citalopram (hence its chemical name “es-citalopram”). The chemical “citalopram” (Celexa) was originally synthesized in 1972 by scientists at …

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Temazepam vs. Xanax: Comparison

Restoril (Temazepam) and Xanax (Alprazolam) are medications of the benzodiazepine classification that originally received U.S. FDA approval in 1981 as treatments for distinct medical interventions.  Temazepam was approved as a short-term treatment for insomnia (intended to be used for 7 to 10 days) – whereas Alprazolam was approved as a treatment for generalized anxiety disorder …

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