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Lurasidone Improves Positive Symptoms of Schizophrenia More Than Negative

MHD featured image for Lurasidone PANSS Domains: Positive Symptoms Lead, Negative Lag.

Lurasidone is approved for schizophrenia and bipolar depression on the strength of acute trials that mostly reported a single number: the change in PANSS total score. A 2026 post-hoc analysis of the JEWEL Phase 3 trial pulls that number apart, looking separately at five symptom domains and at all 30 individual items of the PANSS …

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Latuda Unlikely To Cause Weight Gain; Considered “Weight Neutral”

Latuda (Lurasidone) is a relatively new atypical antipsychotic that was approved in 2013 for the treatment of schizophrenia and depressive episodes in Type 1 Bipolar disorder. Many have made the argument that since this is a “newer” antipsychotic, it’s likely to be “better” than the crop of older medications on the market. While no single …

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