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Mild COVID Cognition Improved After Alpha/Delta and Omicron

A 2026 longitudinal study found reassuring cognitive trajectories after mild-to-moderate COVID-19: Alpha/Delta and Omicron groups both improved by follow-up, and neither group showed persistent neuropsychological test deficits vs. population norms. Psychiatric symptoms and fatigue were also broadly similar across variants.1 Research Highlights 55 adults were assessed: 27 were infected during the Alpha/Delta era and 28 …

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Long COVID Fatigue Was Severe Without Clear Inflammation Biomarkers

MHD featured image for long COVID fatigue biomarkers and inflammation.

A 2026 controlled study of 96 people found severe long-COVID fatigue across 3 validated fatigue scales, but the tested peripheral inflammation, cellular-stress, neuroprotection, and autoimmunity markers did not significantly differ by group or explain fatigue severity.1 The finding argues against a simple blood-marker story, not against the reality of long-COVID fatigue. Research Highlights Fatigue was …

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Long COVID Brain Fog & Cognitive Deficits Linked to Specific Biomarkers

A large prospective study has uncovered two blood biomarker profiles measured during acute COVID-19 that are associated with cognitive deficits months later. Higher fibrinogen and lower C-reactive protein predict both objective and subjective cognitive impairment. Higher D-dimer and lower C-reactive protein predict subjective deficits and occupational impact. Key Facts: In 1,837 COVID-19 patients, two acute …

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