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genetics

Genetic Risk for Low Vitamin D Linked to Lower Social Motivation in First-Episode Psychosis (2024 Study)

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Recent research reveals a notable association between vitamin D levels and the severity of negative symptoms in individuals with first-episode psychosis (FEP). A new study explored the genetic predisposition towards lower vitamin D levels and its impact on symptom severity in schizophrenia and related disorders. Highlights: Vitamin D & Psychosis Connection: Lower levels of vitamin …

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Genetics & Age-Related Cognitive Decline: Insights from TOMORROW Trial (2024 Study)

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In a study utilizing data from the TOMMORROW trial, researchers have embarked on a novel exploration of genetic associations with cognitive change in older individuals. Employing a genome-wide association study (GWAS) approach, they’ve identified specific genetic variants linked to cognitive dynamics, providing new insights into the genetic underpinnings of cognitive change with aging. Highlights: Novel …

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Long-Term Buprenorphine Treatment: The Impact of Genetic & Psychiatric Factors (2024 Study)

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Opioid Use Disorder (OUD) remains a significant public health crisis, with buprenorphine emerging as a key medication in its treatment. Approved by the FDA, buprenorphine works as a partial opioid agonist, helping reduce opioid use and improve treatment retention rates compared to placebo. Despite its effectiveness, challenges in patient retention and optimal treatment duration persist. …

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Autism Spectrum Disorder (ASD): Future Treatments with DNA, mRNA, Protein (CRISPR, ASOs, Drugs)

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Autism Spectrum Disorder (ASD) represents a complex neurodevelopmental challenge with a strong genetic component. Recent advances in molecular biology have opened new avenues for potential therapeutic interventions, targeting the condition at the DNA, mRNA, and protein levels. Highlights: ASD is a genetically diverse condition, with many cases linked to loss-of-function mutations in specific genes. Innovative …

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2 Gene Clusters & Anxiety Disorder Subtypes: Glutamate vs. Serotonin & Dopamine (2023 Study)

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Anxiety disorders (ADs) are a complex set of mental health conditions affecting millions globally. Recent research has made significant strides in understanding the genetic underpinnings of these disorders, linking them to specific brain regions and developmental stages. Highlights: Two Distinct Gene Clusters Identified: Researchers identified two gene clusters with distinct spatial expression profiles in the …

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Genetics of Anxiety Disorders: Insights from Human & Animal Research (2023)

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Anxiety disorders, characterized by excessive or prolonged fear and anxiety, are influenced by both genetic and environmental factors. Recent advancements in genetics and animal model research are shedding light on the intricate neurobiological mechanisms underlying these conditions. Highlights: Anxiety disorders have a moderate heritability, indicating a significant genetic component. Chronic psychosocial stress and traumatic events …

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Mitophagy & Depression: Mitochondrial Autophagy as an Antidepressant Target?

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Depression is a pervasive mental health issue with complex origins and often inadequate treatment options. Recent studies have suggested that mitophagy, the process of selective mitochondrial autophagy, plays a crucial role in the onset and progression of depression, offering new insights into its pathogenesis and potential treatments. Highlights: Major Depressive Disorder (MDD) affects millions globally, …

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