MentalHealthDaily

Zuranolone for Depression: Rapid Efficacy & Safety in Clinical Trials (2023 Review)

Zuranolone, a novel antidepressant, shows promise in treating depression, as evidenced by a recent meta-analysis. A new study investigated zuranolone’s efficacy and safety, focusing on short-term rapid antidepressant effects. Highlights: Zuranolone Effectiveness: Demonstrated significant improvement in depression severity scores compared to placebo, with notable effects by day 15. Treatment-Emergent Adverse Events (TEAEs): Increased incidence in …

Allopregnanolone Agonists for Depression: Brexanolone & Zuranolone in Focus (2023)

by GLOOM

Allopregnanolone agonists represent a promising new class of medications for treating depressive disorders. Evidence suggests that allopregnanolone agonists exhibit rapid-onset of antidepressant action – particularly in women with postpartum depression (PPD). Key facts: Allopregnanolone is a neurosteroid that acts as a positive allosteric modulator of GABAA receptors and is decreased in depressive disorders. The allopregnanolone …

Mixing Xanax and Alcohol: Effects & Dangers

by GLOOM

Xanax (alprazolam) is a drug of the benzodiazepine class originally developed by Upjohn, a Michigan-based pharmaceutical company (now a subsidiary of Pfizer). In the United States, Xanax first received FDA approval for the treatment of panic disorder and hit the market as a prescription medication in 1981. It eventually received subsequent FDA approval for the …

Gabapentin For Opiate Withdrawal

by GLOOM

Gabapentin is rumored to have been synthesized by chemists in the 1970s in attempt to develop an antispasmodic agent. After its synthesis, rights to gabapentin were acquired by Parke-Davis (a subsidiary of Pfizer) whereafter it underwent clinical trials that evaluated its safety and anticonvulsant efficacy in the treatment of seizures. Clinical trial data indicated that …

Baclofen For Opiate Withdrawal Symptom Management

by GLOOM

Baclofen is a drug that was originally synthesized in the early 1960s by Heinrich Keberle, a Swiss chemist employed by the pharmaceutical company Ciba-Geigy. At the time of its synthesis, Keberle hypothesized that baclofen would prove effective as an antiepileptic agent, however, clinical trials yielded unfavorable results. Though ineffective as an antiepileptic, researchers noticed that …

Valerian For Anxiety Disorders

by GLOOM

Valerian (Valeriana officinalis) is a perennial plant named after the Latin term “valere,” which roughly translates to “strong and healthy.” The plant is considered native to Europe and various regions of Asia and tends to bloom pinkish and/or whitish flowers in the summer seasons. Upon blooming, its flowers are universally known to have a sweet, …

Phenibut Withdrawal Symptoms: List of Possibilities

by GLOOM

Phenibut (brand name “Noofen”) is a neuropsychiatric drug originally synthesized in St. Petersburg, Russia by a team of researchers at the Department of Organic Chemistry of the Herzen Pedagogic Institute. By the 1960s, phenibut was introduced as a pharmaceutical agent in Russia for the treatment of various medical conditions including: anxiety, insomnia, and PTSD. Since …