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At-Home TDCS (Transcranial Direct Current Stimulation) for Depression: A Convenient Treatment

A new study provides promising evidence that delivering transcranial direct current stimulation (tDCS) remotely in people’s homes could be an effective treatment approach for major depressive disorder. The key facts are: tDCS is a form of non-invasive brain stimulation that uses electrical currents to modulate activity in targeted brain regions. When applied to the left …

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Adjunct Celecoxib for Depression & Mania: Treatment with a COX-2 Inhibitor

Celecoxib, a selective COX-2 inhibitor, shows promise as an effective and safe adjunct treatment for major depression and mania, according to a new comprehensive systematic review. The analysis also found celecoxib improved symptoms when used as a standalone antidepressant in patients with somatic disorders. However, evidence for efficacy in bipolar depression remains unclear. Key Facts: …

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Case Report: Depression Treated with Deep Brain Focused Ultrasound (2023)

Deep brain stimulation using focused ultrasound leads to rapid remission of severe depression in breakthrough patient case study. Key Facts: Focused ultrasound targeted and suppressed hyperactive areas linked to depression. Stimulation lasted just 64 minutes yet caused depression remission for over 6 weeks. Approach is noninvasive and precisely targeted with no side effects observed. Technology …

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Triple Reuptake Inhibitors For Depression: SNDRI Drugs Outlook

There is a newer class of antidepressant drugs called Triple Reuptake Inhibitors¬†(TRI’s or SNDRI drugs) being developed that target all major neurotransmitters involved in depression: serotonin, norepinephrine, and dopamine. The thought process behind the creation of this new class of triple reuptake inhibitors is that they will target all three major neurotransmitters that are thought …

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