MentalHealthDaily

Rare OCD Variants in NPY5R, DLGAP1, and MAPK8IP3 Segregate in Families

by GLOOM

Editorial card for rare OCD variants in NPY5R, DLGAP1, and MAPK8IP3 across multiplex families.

A 2026 whole-genome sequencing preprint found rare variant signals in 2 multiplex obsessive-compulsive disorder (OCD) families: an NPY5R missense variant in 10 of 15 affected people in 1 pedigree, plus DLGAP1 and MAPK8IP3 signals that tracked all 3 sequenced cases in a branch of a second pedigree.1 The finding is a candidate-gene result, not a …

Copy Number Variants Did Not Moderate ADHD or Autism Outcomes in ALSPAC

by GLOOM

Photoreal illustration of DNA strands and developmental timeline overlaid on a schematic young adult, conveying genetic moderation of childhood neurodevelopmental outcomes.

A 2026 ALSPAC analysis tested a narrow claim behind routine genetic screening for childhood attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD): whether rare copy number variants (CNVs; deleted or duplicated DNA segments) make young-adult outcomes worse than ADHD/ASD status alone would predict. In 8,414 people with usable CNV data, ADHD and ASD predicted worse …