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Lupus Psychosis: 4.5% Prevalence and Antibody Predictors

Stylized illustration of autoantibodies and immune complexes crossing a disrupted blood-brain barrier, evoking the immune-mediated mechanism by which lupus produces psychosis.

Research Highlights Across 65 studies and 31,495 lupus patients, 4.5% develop psychosis (95% CI 3.6–5.5%). Among patients with neuropsychiatric lupus (NPSLE), the rate jumps to 20.5% (95% CI 10.0–37.6%).1 The 4.5% figure is roughly 50 to 100 times higher than the lifetime prevalence of primary psychotic disorders in age-matched general population samples. Psychosis usually shows …

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