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Top Antidepressants to Quit Smoking: Bupropion & Nortriptyline (2023 Evidence Review)

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In the ever-evolving fight against tobacco addiction, the potential of antidepressants, particularly bupropion and nortriptyline, as smoking cessation aids has come into sharp focus. A comprehensive review evaluated the efficacy, potential harms, and tolerability of these medications, providing insights into their role in helping smokers quit. Highlights: Bupropion significantly increases the chances of long-term smoking …

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Dextromethorphan-Bupropion (Auvelity) for Depression: Clinical Trial Data for the New Rapid-Acting Antidepressant

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Major depressive disorder (MDD) is a significant global health concern, affecting over 280 million people worldwide. While numerous pharmacological options exist, challenges remain in achieving timely, robust, and sustained antidepressant response. Dextromethorphan-bupropion is a novel oral antidepressant recently approved by the FDA for MDD in adults that may address some of these unmet needs. Key …

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How Long Does Wellbutrin Stay In Your System?

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Wellbutrin (Bupropion) is an antidepressant that is hypothesized to function as a norepinephrine-dopamine reuptake inhibitor (NDRI).  It is believed to predominantly increase levels of norepinephrine and only affects dopamine to a minor extent.  As a result of its noradrenergic mechanism of action, it is considered “atypical” when compared to other serotonergic antidepressants. Unlike serotonergic antidepressants, Wellbutrin has a …

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Can Wellbutrin Ever Cause Weight Gain? An Uncommon Reaction.

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Wellbutrin (Bupropion) is considered an atypical antidepressant and smoking cessation aid that was first approved for medical use in 1989. It functions different than most antidepressants in that it inhibits the reuptake of stimulatory neurotransmitters norepinephrine and (to a lesser degree) dopamine. Its action as an NDRI drug generally results in increased energy, focus, and …

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Norepinephrine-Dopamine Reuptake Inhibitors (NDRIs) List

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Norepinephrine Dopamine Reuptake Inhibitors (NDRIs) are drugs that function by inhibiting the reuptake of the neurotransmitters norepinephrine and dopamine. This leads to increased neural concentrations of these activating neurotransmitters, resulting in increased stimulation of the central nervous system.  Certain NDRIs inhibit reuptake of norepinephrine to a greater extent than dopamine (and vice versa). Others may have …

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Norepinephrine Reuptake Inhibitors (NRIs) List

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Norepinephrine Reuptake Inhibitors (NRIs) are drugs that function primarily by inhibiting the reuptake of the neurotransmitter norepinephrine (noradrenaline) and/or epinephrine (adrenaline). Inhibiting the reuptake of norepinephrine tends to elicit stimulating effects, thereby increasing both cortical arousal and energy levels. The NRI drugs are typically prescribed to individuals that may benefit from increased arousal such as …

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