MentalHealthDaily

Antidepressants May Trigger Mania In Bipolar Disorder via Mitochondria

Antidepressants, commonly used to treat major depressive episodes in bipolar disorder, might have more profound effects on our body’s energy factories, the mitochondria, than previously understood. A recent study examined how certain antidepressants alter mitochondrial energetics, potentially influencing the risk of treatment-emergent mania in bipolar disorder patients. Highlights: Antidepressants Double Edged Sword: While crucial for …

Mirapex (Pramipexole) For Depression: An Effective Antidepressant?

by GLOOM

Mirapex (Pramipexole) is a drug that is approved by the FDA for the treatment of Parkinson’s disease and RLS (restless leg syndrome). Classified as a dopamine receptor agonist, pramipexole elicits partial or full agonism upon D3 receptors, D2 receptors (2L/2S), and D4 receptors. Interestingly, pramipexole also appears to modify mitochondrial function, and to a negligible …

3 New Bipolar Medications (2015): Drugs In Clinical Trials

by GLOOM

Bipolar disorder is a condition characterized by cyclical mood swings, transitioning from depression to mania (or hypomania). For a period of time, an individual with bipolar disorder will experience debilitating bouts of depression – and often unexpectedly, their entire neurophysiology will shift to facilitate a state of mania (elevated mood). Diagnostically, there are multiple types …

Ketamine For Bipolar Disorder: Treats Anhedonia Prior To Depression

by GLOOM

For years, researchers have been investigating illicit drugs to determine whether they could be used under supervision to treat mental illnesses like depression and bipolar disorder. Although many of these substances have shown promise, in many cases the side effects and addiction potential outweigh any therapeutic benefits. Other times, many drugs may be temporarily helpful …