Mental Health Daily

Online MBCT for Cancer Distress: 9-Month Trial Data

by GLOOM

MHD featured image for online mindfulness-based cognitive therapy and cancer-related distress.

A 2026 analysis followed 161 people with cancer for 9 months to evaluate whether 2 forms of online mindfulness-based cognitive therapy reduced psychological distress: therapist-led group-blended care and individual self-guided modules. Psychological distress improved significantly in both formats, but fewer participants dropped out when the program included therapist-led group sessions. Research Highlights Distress improved through …

Hodgkin Lymphoma Survivors: Occult Sleep Apnea and Fatigue

by GLOOM

A 2026 study of Hodgkin lymphoma survivors treated with mantle radiation found obstructive sleep apnea (OSA) in 36 of 42 people who eventually underwent sleep testing. The practical screening target is a younger, non-obese, positional, hypopnea-heavy post-radiation OSA phenotype that standard risk heuristics can miss.1 Research Highlights Sleep symptoms identified a fatigued subgroup: 45 of …

25C-NBF Psychedelic Shows Antidepressant-Like Effects in Male Rodents

by GLOOM

MHD featured image for 25C-NBF psychedelic psychoplastogenic and antidepressant-like effects in male rodents.

A 2026 preclinical study found that 25C-NBF, a selective 5-HT2A psychedelic phenethylamine, increased plasticity-related markers and produced rapid antidepressant-like effects in male rodents, while showing no detected reward or reinforcement signal in the models tested. Research Highlights 25C-NBF was preclinical: Nadal-Gratacos et al. tested cells, male mice, and male rats, not patients with depression.1 5-HT2A …

Epilepsy and Alzheimer’s Blood Biomarkers in Older Adults

by GLOOM

MHD featured image for epilepsy, Alzheimer’s blood biomarkers, and AT(N) profiles in older adults.

A preprint in 84 older adults with epilepsy found that abnormal Alzheimer's-related blood biomarkers were common, but the biomarker categories did not line up neatly with cognitive impairment. Research Highlights Only 32.1% had normal biomarkers: 27 of 84 older adults with epilepsy were A−T−N− using blood-based amyloid, tau, and neurodegeneration markers.1 AD-continuum profiles were common: …

Chemotherapy Sleep: 87% Poor Quality, 61% Variable Timing

by GLOOM

MHD featured image for chemotherapy sleep quality and sleep timing.

Sleep problems during chemotherapy include more than daytime fatigue. In a 2026 outpatient chemotherapy sample, 87% reported poor sleep quality and 61% had variable sleep timing, while measured bedroom light, temperature, and self-reported environmental disruption were not significantly linked to overall sleep health.1 Research Highlights Small chemotherapy sample: Adams et al. studied 23 adults receiving …

SloCAD Sleep EEG-fMRI Maps Brain Network Deviations Before Diagnosis

by GLOOM

MHD featured image for SloCAD sleep EEG-fMRI network deviation mapping.

A 2026 iScience paper used simultaneous sleep EEG-fMRI from 2 healthy cohorts totaling 24 people to build slow-wave-related BOLD reference maps and propose SloCAD, a framework for measuring how an individual’s slow-wave brain activity deviates from a healthy reference pattern.1 Research Highlights The proof of concept used 24 healthy participants: 2 independent cohorts (N1 = …

Teen Vaping in Thailand: 17.6% Considered E-Cigs Despite Ban

by GLOOM

MHD featured image for teen vaping tendency, e-cigarettes, and youth nicotine risk in Thailand.

A 2026 cross-sectional school study involving 1,848 rural Thai teenagers found that 17.6% reported a tendency to use e-cigarettes, even though Thailand bans e-cigarette sale and importation.1 The strongest adjusted correlate was having ever considered smoking cigarettes: those teenagers had 6.71 times the odds of e-cigarette use tendency compared with teenagers who had never considered …