Depression is a prevalent and serious condition in older adults and those with cardiovascular disease. Serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression, but when they’re ineffective, alternative antidepressants must be considered. Key Facts: Depression in Older Adults and Cardiovascular Patients: Affects 15-20% of patients with coronary heart disease. Limitations of SSRIs: While …
Ketamine causes rapid and sustained antidepressant effects that last longer than its presence in the body. This is due to ketamine getting trapped and accumulating in NMDA receptors, causing prolonged neural inhibition. Manipulating brain activity can shorten or extend ketamine’s effects. Highlights: Ketamine continues blocking NMDA receptors for 24 hours despite rapid elimination from plasma …
A 34-year-old man developed symptoms of frontotemporal dementia (FTD), a rare form of early-onset dementia, after using cannabis for two years. This case highlights the potential risks of long-term cannabis use on brain health, especially for vulnerable individuals. Key Facts: The 34-year-old man used cannabis for two years before experiencing personality changes and behavioral symptoms …
It is estimated that 40% of U.S. adults are obese – and this figure is projected to continue growing. One potential reason for weight gain and a possible catalyst for obesity is use of pharmaceutical drugs (i.e. medications). Medication-induced weight gain poses a significant challenge in healthcare, affecting both patient well-being and treatment adherence. Key …
Obesity now affects over 650 million adults globally and is a major risk factor for various chronic diseases including cognitive decline and impairment. Recent evidence shows a link between obesity, reduced brain volume and neuronal loss, increased dementia risk, and impaired learning, memory and cognition. Preliminary evidence suggests that weight loss drugs like semaglutide may …
Cannabis use is associated with neurological and psychiatric side effects, but the risks of highly potent forms like “moon rocks” are not fully characterized. This case report describes psychosis and new-onset seizures in a 20-year-old following the first-time use of this THC-concentrated preparation. Key Facts: Moon rock cannabis contains high levels of THC, which acts …
Allopregnanolone agonists represent a promising new class of medications for treating depressive disorders. Evidence suggests that allopregnanolone agonists exhibit rapid-onset of antidepressant action – particularly in women with postpartum depression (PPD). Key facts: Allopregnanolone is a neurosteroid that acts as a positive allosteric modulator of GABAA receptors and is decreased in depressive disorders. The allopregnanolone …