Fentanyl is a synthetic opioid drug that was originally synthesized in the early 1960s by Paul Janssen, founder of Janssen Pharmaceutica. The drug initially gained mainstream popularity as a general anesthetic in the 1960s under the brand “Sublimaze”, a compound consisting of fentanyl and citric acid. It wasn’t until the 1990s that fentanyl was approved …
Klonopin (Clonazepam) is a benzodiazepine medication utilized primarily for the treatment of anxiety disorders and acute epilepsy. It is also prescribed off-label for a host of other medical conditions including: acute mania, akathisia, bruxism, insomnia, and restless leg syndrome. As a benzodiazepine, it functions principally by modulating the neurotransmission of GABA (gamma-aminobutyric acid) within the …
Subutex is a drug that was approved by the FDA in 2002 for the treatment of opioid dependence. It is typically utilized as an agent in opioid replacement therapy to help individuals transition off of more potent (often illicit) opioidergic drugs such as oxycodone and heroin. In other words, an individual who was previously ingesting …
Suboxone is a semisynthetic drug manufactured by Reckitt Benckiser pharmaceuticals for the treatment of opioid dependence. It was introduced to the market in October 2002 and gained popularity as a result of its efficacy and reduced potential for abuse compared to other opioid replacement agents such as methadone. The drug is comprised of the ingredients …
Vyvanse (Lisdexamfetamine) is a psychostimulant medication manufactured by Shire Pharmaceuticals for the treatment of ADHD (attention-deficit/hyperactivity disorder). Many consider Vyvanse to be a “new and improved” successor of the drug Adderall. Vyvanse contains the ingredient Lisdexamfetamine which is pharmacologically inactive until metabolized; hence being classified as a “prodrug.” The fact that Vyvanse is a prodrug …
Methadone is a popular synthetic opioid utilized for the treatment of opioid dependence as a “replacement therapy.” Individuals addicted to highly potent opioidergic agents (e.g. heroin) are often prescribed methadone as a transitory “replacement” drug. Administration of methadone as a replacement over heroin is preferred because it is medically viewed as being slightly less addictive. …
Codeine (3-methylmorphine) is an opioid medication commonly prescribed for the treatment of severe coughing (antitussive), mild to moderate pain (analgesic), and/or uncontrollable diarrhea (antidiarrheal). It is considered a natural form of methylated morphine and is the second-most significant alkaloid in opium, accounting for up to 3%. In the United States, codeine is typically manufactured in …