MentalHealthDaily

Adult ADHD Linked to Lower SIRT-1/Nrf-2/HO-1 Antioxidant Defenses

by GLOOM

MHD featured image for adult ADHD, SIRT-1, Nrf-2, HO-1, and antioxidant-defense biomarkers.

A 2026 case-control study found that treatment-naive adults with attention-deficit/hyperactivity disorder (ADHD) had much lower serum SIRT-1, Nrf-2, and HO-1 than matched controls, while TNF-α did not differ. The pattern points more toward impaired antioxidant-defense regulation than a simple broad-inflammation story. Research Highlights Antioxidant-defense markers were lower: adults with ADHD had lower SIRT-1 (9.36 vs. …

NLRP3 Inflammasome & Depression: A Target for Antidepressant Development?

by GLOOM

The NLRP3 inflammasome stands at the crossroads of immune response and mental health, playing a pivotal role in the inflammatory processes implicated in depression. Researchers are exploring the intricate relationship between NLRP3 activation and depressive disorders, highlighting the potential for innovative treatments targeting this complex molecular pathway. Highlights: NLRP3 Inflammasome Activation: NLRP3, a component of …

13 Psychological Benefits of Exercise: On The Brain

by GLOOM

Do you get enough exercise? We live in a culture that has become increasingly sedentary. Back when our ancestors were cavemen, they had to hunt for food, walk long distances, and build things, using their primal strength. The problem has become that many people make excuses to not exercise and actually criticize and/or put down …