A matched case-control study of 50 children with autism spectrum disorder and 50 controls found that newborn amino acid metabolism overlapped with both later autism diagnosis and prenatal air-pollution exposure.1 The central pathway, aspartate and asparagine metabolism, was associated with autism (p = 0.01), pregnancy PM2.5 (p < 0.001), first-trimester PM2.5 (p < 0.001), and …
A 2026 mechanistic review linked microplastics to 6 proposed Alzheimer’s disease pathways and 6 proposed Parkinson’s disease pathways.1 The calibrated interpretation is that microplastics are biologically plausible brain stressors, but the human evidence does not yet prove that they cause Parkinson’s disease or Alzheimer’s disease. Research Highlights Exposure is widespread: the review cited an estimate …
A 2026 meta-analysis of 54 human studies found that 8-hydroxy-2′-deoxyguanosine rose in Parkinson’s disease, while F2-isoprostanes did not show a statistically confirmed Parkinson’s signal; type 2 diabetes showed much larger peripheral oxidative-stress elevations than Parkinson’s disease for both biomarkers. Research Highlights Parkinson’s DNA-oxidation signal was moderate: Msigwa et al. pooled 5 Parkinson’s disease studies with …
A Nature Communications study found that old vertebrate brains lost almost 40% of cysteine protease deubiquitylase catalytic activity with age, despite relatively stable protein abundance.1 Antioxidant treatment with NACET restored DUB activity in aging brains, making the finding a reversible enzyme-mechanism result rather than a generic “antioxidants reverse brain aging” claim. Research Highlights DUB activity …
A 2026 Drosophila Parkinson’s model exposed male and female flies to 500 μM rotenone. By 60 days, male flies had worse survival/climbing than female flies; the paper is a vulnerability screen, not evidence that the same genes are ready human biomarkers.1 Research Highlights 500 μM rotenone split male and female flies: Iyer et al. used …
A 2026 Parkinsonism study involving 63 male rats found that Antrodia cinnamomea plus citrate-stabilized silver nanoparticles reduced 6-OHDA motor, oxidative-stress, inflammatory, α-synuclein, and apoptosis markers, while dopamine and acetylcholine recovery remained nonsignificant. The useful claim is a multitarget preclinical signal, not a Parkinson’s disease treatment recommendation. Research Highlights Combination treatment looked strongest: Tekiner et al. …
A 2026 case-control study found that treatment-naive adults with attention-deficit/hyperactivity disorder (ADHD) had much lower serum SIRT-1, Nrf-2, and HO-1 than matched controls, while TNF-α did not differ. The pattern points more toward impaired antioxidant-defense regulation than a simple broad-inflammation story. Research Highlights Antioxidant-defense markers were lower: adults with ADHD had lower SIRT-1 (9.36 vs. …