nmdar

Published research on nmdar.

BrainJul 7, 2026

NMDAR/TRPM4 Death Complex Blocker Preserved Memory in Alzheimer’s Mice

A 2026 Molecular Psychiatry study found that oral FP802 disrupted the NMDAR/TRPM4 death complex and preserved memory-task performance in 5xFAD Alzheimer’s mice treated for 3 months.1 The fin…

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DrugsFeb 17, 2024

GW043 as Rapid Antidepressant: Partial Agonist of NMDA Receptors (2024 Study)

GW043 emerges as a promising new compound in the treatment of depression showcasing rapid and significant antidepressant effects by targeting NMDA receptors (NMDARs). This mechanism offers h…

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DrugsDec 29, 2023

Prolonged Antidepressant Effect of Ketamine: NMDA Receptors & Lateral Habenula “Trapping”

Ketamine causes rapid and sustained antidepressant effects that last longer than its presence in the body. This is due to ketamine getting trapped and accumulating in NMDA receptors, causing…

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