Mental Health DailyResearch. Evidence. Perspective.Published research on negative symptoms.
A 30-trial meta-analysis found that cholinergic modulators improved schizophrenia negative symptoms, SMD −0.42, while the overall total PANSS/BPRS effect was not statistically significant.1 …
Read articleA 244-person functional MRI study found no significant evidence that ventral striatum activation during reward anticipation works as an endophenotype — a measurable trait used to connect inh…
Read articleClozapine has been the most effective antipsychotic in schizophrenia for almost 40 years, yet it is still routinely held back until patients have failed multiple alternatives over many years…
Read articleLurasidone is approved for schizophrenia and bipolar depression on the strength of acute trials that mostly reported a single number: the change in PANSS total score. A 2026 post-hoc analysi…
Read articleBlack Americans are diagnosed with schizophrenia-spectrum disorders at 2.42 times the rate of White Americans, and they also score higher on negative-symptom measures than White patients car…
Read articleRecent research reveals a notable association between vitamin D levels and the severity of negative symptoms in individuals with first-episode psychosis (FEP). A new study explored the genet…
Read articleResidual schizophrenia is one of the 5 types of schizophrenia that is characterized by a long-term history of negative symptoms (i.e. psychomotor slowing), with very infrequent or rare occur…
Read article
