Lurasidone is approved for schizophrenia and bipolar depression on the strength of acute trials that mostly reported a single number: the change in PANSS total score. A 2026 post-hoc analysis of the JEWEL Phase 3 trial pulls that number apart, looking separately at five symptom domains and at all 30 individual items of the PANSS …
Black Americans are diagnosed with schizophrenia-spectrum disorders at 2.42 times the rate of White Americans, and they also score higher on negative-symptom measures than White patients carrying the same diagnosis.2 A 2026 paper by Spann and colleagues asks why. Research Highlights Black Americans are diagnosed with schizophrenia-spectrum disorders at 2.42x the rate of White Americans, …
Recent research reveals a notable association between vitamin D levels and the severity of negative symptoms in individuals with first-episode psychosis (FEP). A new study explored the genetic predisposition towards lower vitamin D levels and its impact on symptom severity in schizophrenia and related disorders. Highlights: Vitamin D & Psychosis Connection: Lower levels of vitamin …
Residual schizophrenia is one of the 5 types of schizophrenia that is characterized by a long-term history of negative symptoms (i.e. psychomotor slowing), with very infrequent or rare occurrences of positive symptoms. To meet the criteria for diagnosis, the person must have experienced positive symptoms (e.g. hallucinations/delusions/etc.) at some point. With that said, the person …
Schizophrenia is a severe mental illness that is characterized by hallucinations, delusions, and paranoia. Although most people think of “hearing voices” and associate them with schizophrenia, those are just some of the symptoms. The symptoms experienced are divided into two subtypes including “negative” symptoms and “positive” symptoms. Negative symptoms usually involve subtracting something from the …