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How Long Does Flexeril Stay In Your System?

Flexeril (Cyclobenzaprine) is a drug approved by the FDA as a short-term adjunct treatment for skeletal muscle spasms along with physical therapy and rest.  Although its mechanism of action isn’t fully elucidated, it is thought to act within the central nervous system, principally at the brain stem.  Within the brain stem, it is believed to …

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How Long Does Fentanyl Stay In Your System?

Fentanyl is a synthetic opioid drug that was originally synthesized in the early 1960s by Paul Janssen, founder of Janssen Pharmaceutica.  The drug initially gained mainstream popularity as a general anesthetic in the 1960s under the brand “Sublimaze”, a compound consisting of fentanyl and citric acid.  It wasn’t until the 1990s that fentanyl was approved …

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How Long Does Paxil Stay In Your System After Stopping?

Paxil (Paroxetine) is an antidepressant manufactured by GlaxoSmithKline that hit the market in 1992.  It was originally approved by the FDA for the treatment of major depression in adults.  The drug has since received FDA approval to treat a variety of other psychiatric and medical conditions including: generalized anxiety disorder, hot flashes, panic disorder, PTSD, …

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How Long Does Valium Stay In Your System?

Valium (Diazepam) is a popular benzodiazepine medication prescribed for an array of conditions including: acute anxiety, alcohol withdrawal, insomnia, panic attacks, restless leg syndrome, and seizures.  Like other benzodiazepines, diazepam functions as a positive allosteric modulator (PAM) of GABAA receptors.  Rather than binding to the same (“A”) subunit of GABAA receptors as the neurotransmitter GABA …

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How Long Does DMT Stay In Your System? (Dimethyltryptamine)

DMT (N,N-Dimethyltryptamine) is a psychedelic drug derived from the tryptamine family with a similar structure to serotonin and melatonin.  When taken orally, DMT is generally regarded as inactive unless simultaneously ingested with an MAOI (monoamine oxidase inhibitor).  An MAOI prevents the enzyme “monoamine oxidase” from rapidly oxidizing the DMT, thereby facilitating a psychedelic experience. Psychedelic …

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How Long Does Wellbutrin Stay In Your System?

Wellbutrin (Bupropion) is an antidepressant that is hypothesized to function as a norepinephrine-dopamine reuptake inhibitor (NDRI).  It is believed to predominantly increase levels of norepinephrine and only affects dopamine to a minor extent.  As a result of its noradrenergic mechanism of action, it is considered “atypical” when compared to other serotonergic antidepressants. Unlike serotonergic antidepressants, Wellbutrin has a …

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