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Pharmacogenomics (PGx) for Depression: Genetic Analysis to Amplify Antidepressant Efficacy? (2023 Review)

Depression, a leading cause of disability globally, often presents challenges in treatment due to the variability in individual responses to antidepressants. Pharmacogenomic (PGx) testing, an approach aligning treatment with genetic makeup, promises to tailor depression therapy more effectively. Highlights: Major Depressive Disorder (MDD) impacts a significant portion of the global population, with traditional treatments often …

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Celexa (Citalopram) vs. Lexapro (Escitalopram): Which Is Better?

Celexa (citalopram) and Lexapro (escitalopram) are chemically-analogous medications within the selective-serotonin reuptake inhibitor (SSRI) classification that are regularly prescribed for the management of neuropsychiatric disorders.  Chemically, Celexa contains enantiomers S-citalopram and R-citalopram – whereas Lexapro solely contains S-citalopram (hence its chemical name “es-citalopram”). The chemical “citalopram” (Celexa) was originally synthesized in 1972 by scientists at …

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Lexapro (Escitalopram) vs Zoloft (Sertraline): Extensive Comparison

Lexapro (escitalopram) and Zoloft (sertraline) are medications of the selective-serotonin reuptake inhibitor (SSRI) classification utilized most commonly for the management of major depressive disorder (MDD).  Lexapro was co-developed by the pharmaceutical companies Lundbeck and Forest Laboratories (starting in 1997) and received U.S. FDA approval for medical use in 2002. Zoloft was developed by the pharmaceutical …

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Vistaril (Hydroxyzine) vs. Xanax (Alprazolam)

Hydroxyzine, also referred to under its brand names “Vistaril” (hydroxyzine pamoate) and “Atarax” (hydroxyzine hydrochloride), is a first-generation diphenylmethylpiperazine antihistamine.  Alprazolam, most commonly referred to under its brand name “Xanax,” is a benzodiazepine, or more specifically, a triazolobenzodiazepine anxiolytic. In the United States, Vistaril is medically approved as an adjunctive treatment for: psychoneurosis-related anxiety and …

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Etizolam vs. Xanax (Alprazolam): What’s The Difference?

Etizolam and Xanax are interventions that may be utilized for the treatment of acute episodes of anxiety, panic disorder, and/or generalized anxiety disorder.  Although Etizolam has no accepted medical use in the United States where it is federally considered an unregulated “research chemical,” it is regularly utilized in Japan, Italy, and India as a prescription …

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Ativan (Lorazepam) vs. Xanax (Alprazolam): Comparison

Ativan and Xanax are two of the most popular benzodiazepine medications commonly administered for the treatment of anxiety.  Ativan is indicated (FDA approved) for the treatment of anxiety disorders, acute anxiety, and/or anxiety associated with depressive symptoms – and Xanax is indicated (FDA approved) for the treatment of anxiety disorders and panic disorder. D.J. Richards, …

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Prozac vs. Zoloft: Comparison (Similarities & Differences)

Prozac and Zoloft are two common SSRI medications prescribed for the treatment of neuropsychiatric conditions, most notably, major depressive disorder (MDD).  Prozac was developed by the pharmaceutical company Eli Lilly and went on to receive initial FDA approval in December 1987 as an antidepressant. Comparatively, Zoloft was developed by the pharmaceutical company Pfizer and went …

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