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Sancai Acupuncture for Primary Insomnia: 13-Point ISI Drop vs. Sham

MHD featured image for Sancai acupuncture and primary insomnia treatment in a sham-controlled trial.

A 2026 randomized sham-controlled trial in 76 adults with primary insomnia found an 8-week Sancai acupuncture protocol reduced post-treatment Insomnia Severity Index scores to 7.80 vs. 16.45 with sham acupuncture, while total sleep time increased to 366.83 minutes vs. 287.97 minutes.1 Research Highlights Insomnia severity fell far more with real acupuncture: Zhao et al. randomized …

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Dexamethasone Disrupts Mouse Sleep Through Orexin Hyperarousal

Photoreal illustration of a steroid pill bottle with overlay of disrupted sleep architecture, conveying glucocorticoid-induced insomnia mechanism.

A 2026 male-mouse study found that 30 mg/kg dexamethasone for 5 days increased light-phase wakefulness (t13 = 4.122, p = 0.0012), decreased NREM sleep (t13 = 4.412, p = 0.0007), and amplified orexin-neuron activity during NREM-to-wake transitions (F1,9 = 6.941, p = 0.0272). The result points to orexin-linked hyperarousal as a testable explanation for steroid-induced …

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Valerian Root for Insomnia & Sleep: Is It Actually Effective? (2023 Review)

Valerian, a herb long cherished for its sedative properties, stands at the crossroads of traditional medicine and modern scientific inquiry. Despite its widespread use across cultures for promoting sleep and alleviating insomnia, the scientific community remains divided over its efficacy. Highlights: Historical Significance: Valerian has been used since the times of ancient Greece and Rome …

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tDCS for Insomnia & Sleep Disturbances: Targeting the Infralimbic Cortex to Ventrolateral Preoptic Area Pathway (2024 Study)

In the quest to effectively treat insomnia, a condition plaguing millions worldwide, scientists are exploring innovative treatments beyond traditional medication. Transcranial Direct Current Stimulation (tDCS) emerges as a promising intervention, offering a non-invasive method to modulate brain activity and enhance sleep quality. A recent study suggests tDCS may treat stress-related sleep disturbances and highlights the …

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Medical Cannabis for Generalized Anxiety Disorders & Sleep Disturbances (2023 Study)

Recent research has shed light on the potential benefits of cannabis-based medicinal products (CBMPs) in treating Generalized Anxiety Disorder (GAD), especially in patients with sleep disturbances. Recent research explored the effectiveness of CBMPs on GAD, the role of sleep quality in treatment outcomes, and the incidence of adverse events. Highlights: CBMPs Show Promise in Treating …

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