Mental Health DailyResearch. Evidence. Perspective.Published research on hpa axis.
In a 2026 study of 48 male rats with fear-conditioned anxiety, 10 days of schisandrin B at 10 or 20 mg/kg increased time in the open arms of an elevated plus maze, similar to diazepam, but n…
Read articleA 2026 rat study found that activating PACAP signaling in the lateral septum amplified stress-hormone release and anxiety-like behavior, while blocking endogenous PACAP receptors produced an…
Read articleA 2026 Communications Biology rat study found that enriched housing reversed early-life-stress visceral hypersensitivity and depression-like behavior by normalizing a CB1 receptor-linked pre…
Read articleA 2026 review of 52 studies found that chronic primary pain is linked to several physiological stress markers, especially cortisol, heart rate, heart-rate recovery, and mean arterial pressur…
Read articleA 2025 longitudinal analysis of 1,528 older Chinese Americans by Chen et al. in the Journal of Prevention of Alzheimer’s Disease says something more specific than “stress causes Alzheimer’s”…
Read articleA 2026 male-mouse study found that 30 mg/kg dexamethasone for 5 days increased light-phase wakefulness (t13 = 4.122, p = 0.0012), decreased NREM sleep (t13 = 4.412, p = 0.0007), and amplifie…
Read articleIn a world increasingly burdened by the psychological strains of modern living, the quest for effective and safe treatments for stress-related symptoms has never been more urgent. A recent s…
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