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PGAM5 Genetics & Depression via ATP Levels in the Prefrontal Cortex (2023 Mouse Study)

Major depressive disorder (MDD) is a complex and prevalent psychiatric condition that affects millions worldwide, yet its underlying mechanisms remain only partially understood. Recent research sheds light on the critical roles of phosphoglycerate mutase family member 5 (PGAM5) and adenosine triphosphate (ATP) in the brain, offering new insights into how disruptions in energy metabolism can …

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Genetics Predict Suicide Risk in U.S. Army Soldiers (2024 Polygenic Analysis)

Suicide remains a leading cause of death worldwide, with its prevention a top priority for both public health initiatives and individual care strategies. Recent research in the US Army offers new insights into the genetic underpinnings of suicide attempts, suggesting that polygenic risk scores (PRS) could become a valuable tool in identifying individuals at risk. …

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Genetics & Age-Related Cognitive Decline: Insights from TOMORROW Trial (2024 Study)

In a study utilizing data from the TOMMORROW trial, researchers have embarked on a novel exploration of genetic associations with cognitive change in older individuals. Employing a genome-wide association study (GWAS) approach, they’ve identified specific genetic variants linked to cognitive dynamics, providing new insights into the genetic underpinnings of cognitive change with aging. Highlights: Novel …

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