Mental Health DailyResearch. Evidence. Perspective.Published research on dopamine.
A 2026 rat study found that foot-shock stress transiently reduced food-cue approach during the first 2 conditioned-stimulus trials (t = 2.807; P < 0.05), and inhibiting the nucleus of the so…
Read articleA 2025 iScience study found that nighttime caffeine increased motor impulsivity in Drosophila, with dose-dependent loss-of-inhibition events across n = 30-32 flies per behavioral condition a…
Read articleA 2026 Nature Neuroscience study from the Igarashi lab proposes a circuit-level answer for why the lateral entorhinal cortex (LEC) is the first cortical region to falter in Alzheimer’s: dopa…
Read articleRestless legs syndrome (RLS) and opioid-withdrawal restlessness both produce night-worsening urges to move. A 2026 npj Parkinson’s Disease mouse study tied that overlap to hypersensitive str…
Read articleA 2026 iScience study recorded 27 substantia nigra neurons during deep-brain-stimulation surgery in 11 Parkinson’s disease patients and found that prior reward shaped both putative dopamine-…
Read articleA 2026 Parkinson’s disease study used gene-expression data and genome-scale metabolic modeling to predict patient-level metabolite patterns, then separated 104 patients into 3 metabolic subg…
Read articleChronic stress is a candidate mechanism for both depression and addiction risk. A 2026 mouse study found that 28 days of unpredictable chronic mild stress increased striatal dopamine D1 rece…
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