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Reset Modafinil Tolerance with Drug Holidays & Pitolisant-Bridging? (2023 Study)

Narcolepsy, a chronic neurological disorder, significantly impacts the daily lives of those affected due to excessive daytime sleepiness (EDS). Modafinil has been a cornerstone in managing EDS, but its effectiveness can wane over time due to tolerance. An innovative approach, using the drug pitolisant during modafinil ‘drug holidays’, offers new hope for resetting tolerance and …

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Epigenetics & Nicotine Addiction: Effects on Genes & Potential Treatments (2023)

Nicotine addiction is not just a habit; it’s a complex interplay of molecular changes altering the brain’s function and structure. Recent research sheds light on how nicotine interacts with our genetic makeup, leading to persistent cravings and relapse. Highlights: Nicotine & Epigenetic Modification: Nicotine alters the way genes are expressed in the brain, affecting behavior …

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Antidepressant Dependence: Psychological & Physiological Aspects

Many people taking antidepressants find them extremely helpful for managing depression, anxiety, and other phobias. A considerable number of people get benefit from antidepressant medication and without them, they wouldn’t be able to hold down a job or maintain a social life. For certain people, antidepressants are a godsend and enhance certain neurotransmitters to alleviate …

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Are Antidepressants Addictive? It’s Debatable.

Addiction is defined as repeatedly engaging in a particular behavior or using a substance to experience pleasure, regardless of the consequences. Some believe that addiction can be a result of environmental experiences and/or various psychological conditions. When most people think of addiction, they think of gambling, illicit drugs (e.g. cocaine), alcohol, and sex. One reason …

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